Neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced apoptosis in cultured cortical neurons

Yi Chien Lin, Li Chen Chou, Sheng Chih Chen, Sheng Chu Kuo, Li Jiau Huang, Po Wu Gean

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

Ceramide accumulation in neurons during various disorders is associated with acute and chronic neurodegeneration. Here we investigate the neuroprotective effects of furopyrazole derivative of benzylindazole analogs on C2 ceramide-induced cell death in primary cortical neurons. Among the 12 furopyrazole derivative of benzylindazole analogs tested, carbinol derivatives exhibited strongest neuroprotection against C2 ceramide-induced apoptosis. The results suggest that furopyrazole derivative of benzylindazole analogs can be developed as useful neuroprotectants against neurodegenerative diseases.

原文English
頁(從 - 到)3225-3228
頁數4
期刊Bioorganic and Medicinal Chemistry Letters
19
發行號12
DOIs
出版狀態Published - 2009 六月 15

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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