TY - JOUR
T1 - New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR
AU - Stanya, Kristopher J.
AU - Kao, Hung Ying
N1 - Funding Information:
We would like to thank Drs. E. Reineke and D. Samols for critical comments on the manuscript. H.Y. Kao is supported by Pardee Foundation, American Cancer Society, and NIH (DK078965).
PY - 2009/4/21
Y1 - 2009/4/21
N2 - Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.
AB - Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.
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U2 - 10.1186/1747-1028-4-7
DO - 10.1186/1747-1028-4-7
M3 - Review article
C2 - 19383165
AN - SCOPUS:65549128635
SN - 1747-1028
VL - 4
JO - Cell Division
JF - Cell Division
M1 - 7
ER -