New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

Kristopher J. Stanya, Hung Ying Kao

研究成果: Review article

26 引文 (Scopus)

摘要

Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.

原文English
文章編號7
期刊Cell Division
4
DOIs
出版狀態Published - 2009 四月 21

指紋

Co-Repressor Proteins
Thyroid Hormone Receptors
Estrogen Receptor Modulators
Retinoids
Cytoplasmic and Nuclear Receptors
Histones
Cell Cycle
Proteins
Transcription Factors
Cells
Breast Neoplasms
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

引用此文

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