New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

Kristopher J. Stanya, Hung Ying Kao

研究成果: Review article

28 引文 斯高帕斯(Scopus)

摘要

Corepressors are large proteins that facilitate transcriptional repression through recruitment of histone-modifying enzymes. Two major corepressors, SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor corepressor), have been shown to mediate repression associated with nuclear receptors and a myriad of other transcription factors. This review will focus on recent studies on these proteins, including newly discovered physiological roles of the corepressors, their modes of regulation, their roles in antiestrogen-resistant breast cancer and their functions during the cell cycle.

原文English
文章編號7
期刊Cell Division
4
DOIs
出版狀態Published - 2009 四月 21

    指紋

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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