New progress in iron chelation therapy

研究成果: Article

摘要

Iron is required for many enzymes which are critical for cellular functions and plays an important role in oxygen carrying proteins, e.g. hemoglobin. But it can be toxic when present in excess. Therefore, the total body iron store should be kept within defined limits. When there is excess of iron in the body, it is called iron overload. If it is untreated, it will damage the target organs, including the heart, liver and endocrine organs. Clinically we can use phlebotomy or iron chelators to treat iron overload. In the past 3 or 4 decades, only one available iron chelator "deferoxamine" can be used. However, poor compliances and inconvenience are major problems. During the past few years the advances on iron chelation research has been impressive, leading to the development of new oral iron chelators including deferiprone and deferasirox. The new treatment options greatly enhance the efficacy of iron chelation for preventing and treating the iron overload complications. Whichever iron chelator is chosen, patients should be closely monitored both for effectiveness of therapy and for toxic side effects.

原文English
頁(從 - 到)48-57
頁數10
期刊Journal of Internal Medicine of Taiwan
20
發行號1
出版狀態Published - 2009 二月 1

指紋

Chelation Therapy
Iron
Chelating Agents
Iron Overload
Poisons
Deferoxamine
Phlebotomy
Hemoglobins
Oxygen

All Science Journal Classification (ASJC) codes

  • Internal Medicine

引用此文

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abstract = "Iron is required for many enzymes which are critical for cellular functions and plays an important role in oxygen carrying proteins, e.g. hemoglobin. But it can be toxic when present in excess. Therefore, the total body iron store should be kept within defined limits. When there is excess of iron in the body, it is called iron overload. If it is untreated, it will damage the target organs, including the heart, liver and endocrine organs. Clinically we can use phlebotomy or iron chelators to treat iron overload. In the past 3 or 4 decades, only one available iron chelator {"}deferoxamine{"} can be used. However, poor compliances and inconvenience are major problems. During the past few years the advances on iron chelation research has been impressive, leading to the development of new oral iron chelators including deferiprone and deferasirox. The new treatment options greatly enhance the efficacy of iron chelation for preventing and treating the iron overload complications. Whichever iron chelator is chosen, patients should be closely monitored both for effectiveness of therapy and for toxic side effects.",
author = "Ya-Ping Chen and Wu, {Hung Chang} and Yu-Min Yeh and Chang, {Kwang Yu} and Wei-Hsin Chiu and Wen-Pin Su and Peng-Chan Lin and Chia-Jui Yen and Wu-Chou Su and Tsai-Yun Chen",
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AU - Su, Wen-Pin

AU - Lin, Peng-Chan

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AU - Su, Wu-Chou

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