NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX

研究成果: Article

15 引文 斯高帕斯(Scopus)

摘要

The effect of 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a specific non-N-methyl-d-aspartate (non-NMDA) receptor antagonist, on NMDA-independent epileptiform activity induced by Mg2+-free medium was studied in rat basolateral amygdala (BLA) neurons using intracellular recording techniques. Twenty to 30 min after switching to Mg2+-free medium, spontaneous and evoked epileptiform activity were observed in 16 out of 18 amygdala slices. Superfusion of d-2-amino-5-phosphonovalerate (d-APV), a selective NMDA receptor antagonist, reduced the duration of epileptiform activity by an average of 83%. However, there was a residual depolarizing component which remained in the presence of d-APV. This d-APV-resistant component could be completely blocked by CNQX suggesting that it is mediated by non-NMDA receptors.

原文English
頁(從 - 到)53-55
頁數3
期刊Neuroscience Letters
119
發行號1
DOIs
出版狀態Published - 1990 十月 30

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

指紋 深入研究「NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX」主題。共同形成了獨特的指紋。

  • 引用此