No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations

Ru Band Lu, Huei Chen Ko, Fong Ming Chang, Carmela M. Castiglione, Gloria Schoolfield, Andrew J. Pakstis, Judith R. Kidd, Kenneth K. Kidd

研究成果: Article同行評審

78 引文 斯高帕斯(Scopus)

摘要

This study examined whether there is evidence for an association between alcoholism and the alleles of the TaqI A, TaqI B, and short tandem repeat polymorphisms (STRP), both individually and as haplotypes, at the dopamine D2 receptor gene (DRD2) in males of three populations from Taiwan. We studied 46 Chinese Han (21 alcoholics and 25 nonalcoholics), 42 Atayal (21 alcoholics and 21 nonalcoholics), and 40 Ami (20 alcoholics and 20 nonalcoholics). Alcoholism was diagnosed according to DSM-III-R criteria and all individuals in the alcoholic groups were severely affected. Significant linkage disequilibrium occurs for the three polymorphic sites in all three populations. No significant association was observed between any of the three polymorphisms at the DRD2 locus, tested individually and as haplotypes, and alcoholism in the three subject groups. We conclude that no association exists between genetic variation at the DRD2 locus and alcoholism in Chinese Han, Atayal, and Ami males.

原文English
頁(從 - 到)419-429
頁數11
期刊Biological Psychiatry
39
發行號6
DOIs
出版狀態Published - 1996 三月 15

All Science Journal Classification (ASJC) codes

  • 生物精神病學

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