Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia

Lori C. Jordan, Melissa C. Gindville, Allison O. Scott, Meher R. Juttukonda, Megan K. Strother, Adetola A. Kassim, Sheau Chiann Chen, Hanzhang Lu, Sumit Pruthi, Yu Shyr, Manus J. Donahue

研究成果: Article同行評審

90 引文 斯高帕斯(Scopus)

摘要

Sickle cell anaemia is a monogenetic disorder with a high incidence of stroke. While stroke screening procedures exist for children with sickle cell anaemia, no accepted screening procedures exist for assessing stroke risk in adults. The purpose of this study is to use novel magnetic resonance imaging methods to evaluate physiological relationships between oxygen extraction fraction, cerebral blood flow, and clinical markers of cerebrovascular impairment in adults with sickle cell anaemia. The specific goal is to determine to what extent elevated oxygen extraction fraction may be uniquely present in patients with higher levels of clinical impairment and therefore may represent a candidate biomarker of stroke risk. Neurological evaluation, structural imaging, and the noninvasive T2-relaxation-under-spin-tagging magnetic resonance imaging method were applied in sickle cell anaemia (n = 34) and healthy race-matched control (n = 11) volunteers without sickle cell trait to assess whole-brain oxygen extraction fraction, cerebral blood flow, degree of vasculopathy, severity of anaemia, and presence of prior infarct; findings were interpreted in the context of physiological models. Cerebral blood flow and oxygen extraction fraction were elevated (P < 0.05) in participants with sickle cell anaemia (n = 27) not receiving monthly blood transfusions (interquartile range cerebral blood flow = 46.2-56.8 ml/100 g/min; oxygen extraction fraction = 0.39-0.50) relative to controls (interquartile range cerebral blood flow = 40.8-46.3 ml/100 g/min; oxygen extraction fraction = 0.33-0.38). Oxygen extraction fraction (P < 0.0001) but not cerebral blood flow was increased in participants with higher levels of clinical impairment. These data provide support for T2-relaxation-under-spin-tagging being able to quickly and non-invasively detect elevated oxygen extraction fraction in individuals with sickle cell anaemia with higher levels of clinical impairment. Our results support the premise that magnetic resonance imaging-based assessment of elevated oxygen extraction fraction might be a viable screening tool for evaluating stroke risk in adults with sickle cell anaemia.

原文English
頁(從 - 到)738-750
頁數13
期刊Brain
139
發行號3
DOIs
出版狀態Published - 2016 3月 1

All Science Journal Classification (ASJC) codes

  • 神經病學(臨床)

指紋

深入研究「Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia」主題。共同形成了獨特的指紋。

引用此