Non-thermal reactive n2/he plasma exposure to inhibit epithelial head and neck tumor cells

Chih Ying Wu, Jiunn-Der Liao, Chang Han Chen, Han Lee, Shyh Hau Wang, Bernard Haochih Liu, Cheng Yi Lee, Pei Lin Shao, Enya Li

研究成果: Article同行評審

摘要

The traditional therapy for head and neck cancer patients has several side effects. Hence, regular follow-up care is usually required. Recently, non-thermal micro-plasma was applied to inactivate cancer cells. Such a physical method provides localized energy and reactive oxygen/nitrogen species (ROS/RNS). In this study, the ability of non-oxygen N2/He micro-plasma to inactivate four pharynx squamous carcinomatous cells, namely SAS, CAL 27, FaDu, and Detroit 562, under different exposure durations is evaluated. The four cell lines were affected with regard to proliferation, reduction, and apoptosis-related DNA damage, implying that the cell medium is critical in plasma–cell interaction. This is expected to be a promising method for head and neck cancer cell suppression through plasma-initiated ROS/RNS species under a suitable exposure time.

原文English
文章編號1284
期刊Coatings
11
發行號11
DOIs
出版狀態Published - 2021 十一月

All Science Journal Classification (ASJC) codes

  • 表面和介面
  • 表面、塗料和薄膜
  • 材料化學

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