Noninferiority studies with multiple reference treatments

Huang Li-Ching, Wen Miin-Jye, Cheung Siu Hung, Kwong Koon Shing

研究成果: Article

2 引文 斯高帕斯(Scopus)

摘要

The increasing popularity of noninferiority trials reflects the ongoing efforts to replace existing treatments (reference treatments) with new treatments (experimental treatments) that retain a substantial fraction of the effect of the reference treatments. The adoption of any new treatment has to be vindicated by a demonstration of benefits that outweigh a possible clinically insignificant reduction in the reference treatment efficacy. Statistical methods have been developed to analyze data collected from noninferiority trials. However, these methods focus on cases with only one reference treatment. In this paper, we provide the statistical inferential procedures for situations with multiple reference treatments. The computation of the corresponding critical values for simultaneous testings of noninferiority of several new treatments to multiple reference treatments in the presence of a placebo is provided. Furthermore, for a prespecified level of test power, a technique to determine the optimal sample size before the onset of a noninferiority trial is derived. A clinical example is given to illustrate our proposed procedure.

原文English
頁(從 - 到)1295-1307
頁數13
期刊Statistical Methods in Medical Research
26
發行號3
DOIs
出版狀態Published - 2017 六月 1

    指紋

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

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