TY - JOUR
T1 - Noninvasive evaluation of collagen and hemoglobin contents and scattering property of in vivo keloid scars and normal skin using diffuse reflectance spectroscopy
T2 - Pilot study
AU - Tseng, Sheng Hao
AU - Hsu, Chao Kai
AU - Lee, Julia Yu Yun
AU - Tzeng, Shih Yu
AU - Chen, Wan Rung
AU - Liaw, Yu Kai
N1 - Funding Information:
We thank Dr. Andrea Bassi for kindly providing the absorption spectrum of collagen. Dr. Tseng would like to acknowledge the support provided by the National Science Council of Taiwan under Grant No. NSC-100-2628-E-006-007.
PY - 2012/7
Y1 - 2012/7
N2 - Collagen is a rich component in skin that provides skin structure integrity; however, its contribution to the absorption and scattering properties of various types of skin has not been extensively studied. We considered the contribution of the collagen to the absorption spectrum of in vivo normal skin and keloids of 12 subjects derived from our diffuse reflectance spectroscopy (DRS) system in the wavelength range from 550 to 860 nm. It was found that the collagen concentration, the hemoglobin oxygen saturation, and the reduced scattering coefficient of keloids were remarkably different from that of normal skin. Our results suggest that our DRS system could assist clinicians in understanding the functional and structural condition of keloid scars. In the future, we will evaluate the accuracy of our system in the keloid diagnosis and investigate the applicability of our system for other skin-collagen-related studies.
AB - Collagen is a rich component in skin that provides skin structure integrity; however, its contribution to the absorption and scattering properties of various types of skin has not been extensively studied. We considered the contribution of the collagen to the absorption spectrum of in vivo normal skin and keloids of 12 subjects derived from our diffuse reflectance spectroscopy (DRS) system in the wavelength range from 550 to 860 nm. It was found that the collagen concentration, the hemoglobin oxygen saturation, and the reduced scattering coefficient of keloids were remarkably different from that of normal skin. Our results suggest that our DRS system could assist clinicians in understanding the functional and structural condition of keloid scars. In the future, we will evaluate the accuracy of our system in the keloid diagnosis and investigate the applicability of our system for other skin-collagen-related studies.
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U2 - 10.1117/1.JBO.17.7.077005
DO - 10.1117/1.JBO.17.7.077005
M3 - Article
C2 - 22894518
AN - SCOPUS:84872041636
SN - 1083-3668
VL - 17
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 7
M1 - 077005
ER -