Noninvasive hemoglobin quantification across different cohorts using a wearable diffuse reflectance spectroscopy system

Chen Ying-Yu, Lai Guan-Hua, Chen Chia-Te, Cheng Hsiu-Chi, Tseng Sheng-Hao

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Quantifying hemoglobin is vital yet invasive through blood draws. We developed a wearable diffuse reflectance spectroscopy device comprising control and sensor boards with photodiodes and light-emitting diodes to noninvasively determine hemoglobin. Neural networks enabled recovery of optical parameters for chromophore fitting to calculate hemoglobin. Testing healthy and elderly subjects revealed strong correlation (r=0.9) between our system and invasive methods after data conversion. Bland-Altman analysis demonstrated tight 95% limits of agreement from −1.98 to 1.98 g/dL between the DRS and invasive hemoglobin concentrations. By spectroscopically isolating hemoglobin absorption, interference from melanin was overcome. Our device has the potential for future integration into wearable technology, enabling hemoglobin level tracking.

原文English
頁(從 - 到)1739-1749
頁數11
期刊Biomedical Optics Express
15
發行號3
DOIs
出版狀態Published - 2024 3月 1

All Science Journal Classification (ASJC) codes

  • 生物技術
  • 原子與分子物理與光學

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