Nonionic microemulsions as solubilizers of hydrophobic drugs: Solubilization of paclitaxel

研究成果: Article

2 引文 (Scopus)

摘要

The strategy using nonionic microemulsion as a solubilizer for hydrophobic drugs was studied and is demonstrated in this work. The aqueous phase behaviors of mixed nonionic surfactants with various oils at 37°C are firstly constructed to give the optimal formulations of nonionic microemulsions with applications in the enhanced solubilization of the model hydrophobic drug, paclitaxel, at 37°C. Briefly, the suitable oil phase with paclitaxel significantly dissolved is microemulsified with appropriate surfactants. Surfactants utilized include Tween 80, Cremophor EL, and polyethylene glycol (4.3) cocoyl ether, while various kinds of edible oils and fatty esters are used as the oil phase. On average, the apparent solubility of paclitaxel is increased to ca. 70-100 ppm in the prepared microemulsions at 37°C using tributyrin or ethyl caproate as the oil phases. The sizes of the microemulsions attained are mostly from ca. 60 nm to ca. 200 nm. The cytotoxicity of the microemulsion formulations is assessed with the cellular viability of 3T3 cells. In general, the cell viability is above 55% after 24 h of cultivation in media containing these microemulsion formulations diluted to a concentration of total surfactants equal to 50 ppm and 200 ppm.

原文English
文章編號761
期刊Materials
9
發行號9
DOIs
出版狀態Published - 2016 九月

指紋

Microemulsions
Paclitaxel
Oils
Surface-Active Agents
Pharmaceutical Preparations
Surface active agents
Polysorbates
Nonionic surfactants
Phase behavior
Cytotoxicity
Oils and fats
Ether
Polyethylene glycols
Ethers
Esters
Solubility
Cells

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

引用此文

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