Offshore bridges play an important role under multi-hazard circumstances. Hence, it is necessary to consider the soil and structure interaction when we design a bridge subjected to dynamic loading. In this study, the ABAQUS finite element program is used to analyze the performance of bridge pier under soil and structure interaction. The finite element model of soil adapted the soil spring built upon the empirical equation proposed by API. To verify the feasibility of the soil spring model, the results of the nature frequency between the sandbox test and ABAOUS analysis are compared. It has been demonstrated that ABAQUS can solve the natural frequencies and vibration modes of bridge piers reliably. In addition, the displacement responses under earthquake between the sandbox test and soil spring model are compared and good agreement is obtained. Finally, a realistic highway bridge in Taiwan subjected to earthquake is analyzed and important conclusions are given.