Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases

Chien Fang Huang, Po Lin Chen, Ming Fei Liu, Ching Chi Lee, Nan Yao Lee, Chia Ming Chang, Hsin Chun Lee, Chi Jung Wu, Wen Chien Ko

研究成果: Article

9 引文 (Scopus)

摘要

Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

原文English
頁(從 - 到)350-355
頁數6
期刊Journal of Microbiology, Immunology and Infection
45
發行號5
DOIs
出版狀態Published - 2012 十月 1

指紋

Connective Tissue Diseases
Bacteremia
Salmonella
Focal Infection
Mortality
Systemic Lupus Erythematosus
Age Factors
Immunocompromised Host
Immunosuppressive Agents
Microbiology
Acute Kidney Injury
Medical Records
Shock
Adrenal Cortex Hormones
Databases
Morbidity

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

引用此文

Huang, Chien Fang ; Chen, Po Lin ; Liu, Ming Fei ; Lee, Ching Chi ; Lee, Nan Yao ; Chang, Chia Ming ; Lee, Hsin Chun ; Wu, Chi Jung ; Ko, Wen Chien. / Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases. 於: Journal of Microbiology, Immunology and Infection. 2012 ; 卷 45, 編號 5. 頁 350-355.
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abstract = "Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4{\%}) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9{\%} (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7{\%} of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.",
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Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases. / Huang, Chien Fang; Chen, Po Lin; Liu, Ming Fei; Lee, Ching Chi; Lee, Nan Yao; Chang, Chia Ming; Lee, Hsin Chun; Wu, Chi Jung; Ko, Wen Chien.

於: Journal of Microbiology, Immunology and Infection, 卷 45, 編號 5, 01.10.2012, p. 350-355.

研究成果: Article

TY - JOUR

T1 - Nontyphoidal Salmonella bacteremia in patients with connective tissue diseases

AU - Huang, Chien Fang

AU - Chen, Po Lin

AU - Liu, Ming Fei

AU - Lee, Ching Chi

AU - Lee, Nan Yao

AU - Chang, Chia Ming

AU - Lee, Hsin Chun

AU - Wu, Chi Jung

AU - Ko, Wen Chien

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

AB - Background/Purpose: Nontyphoidal Salmonella (NTS) is a crucial pathogen in immunocompromised patients, especially those with connective tissue disease (CTD) and corticosteroid or immunosuppressant therapy. The aim of this study is to identify the clinical characteristics and outcomes of patients with CTD and NTS bacteremia, and the clinical variations between systemic lupus erythematosus (SLE) and other CTDs. Methods: During a 15-year study period, from 1994 to 2009, NTS bacteremia patients were reviewed from the database of clinical microbiology laboratory. Medical records were reviewed for clinical information and only patients with underlying CTD were included. Results: From 1994 to 2009, there were 299 patients with NTS bacteremia. Forty-six (15.4%) patients had certain connective tissue diseases, and SLE was the major CTD, accounting for 73.9% (34) of 46 patients. In comparison with patients without CTD, the patients with CTD were younger (p<. 0.0001), had a predominance of female gender (p<. 0.0001), fewer extra-intestinal focal infections (p= 0.011), and a lower mortality rate (p= 0.008). Overall, there were four fatal cases, accounting for a mortality rate of 8.7% of those afflicted with CTD. The factors of old age (p<. 0.006), shock at presentation (p= 0.033), acute renal failure (p= 0.001), and presence of any extra-intestinal focal infection (p<. 0.0001) were associated with mortality in the univariate analysis. Conclusion: Nontyphoidal Salmonella bacteremia causes substantial morbidity and mortality in patients with connective tissue disease, especially in the elderly population. The aggressive detection of extra-intestinal infections may be beneficial.

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