Novel Compliance Index derived from digital volume pulse associated with risk factors and exercise capacity in patients undergoing treadmill exercise tests

Ju Yi Chen, Wei Chuan Tsai, Ming Sheng Wu, Chih Hsin Hsu, Chih Chan Lin, Hsien Tsai Wu, Li Jen Lin, Jyh Hong Chen

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

OBJECTIVE: Although large-artery stiffness is a well-known independent factor for cardiovascular risk, the importance of small-artery stiffness is not well elucidated. We have developed a novel Compliance Index as a marker of small-artery stiffness. This study aimed to determine the clinical significance of this index by evaluating 140 patients without left ventricular dysfunction referred for treadmill exercise tests. METHODS: Immediately after a 10-min rest period before the test, the pulse wave velocity and Compliance Index were measured. The patients were then given a symptom-limited treadmill test using Bruce's protocol. Our dual-channel photoplethysmography system automatically measured the area under the curve of each digital volume pulse, which represented the volume change in the finger with each heart beat. The Compliance Index was calculated by dividing the area under the curve of finger digital volume pulse by pulse pressure. RESULTS: The Compliance Index was significantly correlated with pulse wave velocity (r = -0.254, P = 0.002), systolic blood pressure (r = -0.606, P < 0.001), and diastolic blood pressure (r = -0.323, P < 0.001). It was lower in males (3.3 ± 1.4 versus 4.8 ± 2.4 units, P < 0.001), in hypertensive patients (3.2 ± 1.5 versus 4.4 ± 2.2 units, P < 0.001), and in smokers (3.0 ± 1.5 versus 4.1 ± 2.1 units, P = 0.006). CONCLUSIONS: The Compliance Index was lower in patients with risk factors and was associated with poor exercise capacity. This index may be clinically useful for evaluating arterial stiffness.

原文English
頁(從 - 到)1894-1899
頁數6
期刊Journal of hypertension
25
發行號9
DOIs
出版狀態Published - 2007 9月

All Science Journal Classification (ASJC) codes

  • 內科學
  • 生理學
  • 心臟病學與心血管醫學

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