Novel concept on antiviral strategies to dengue

研究成果: Review article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Recent evidence has revealed that asymptomatic and/or persistent dengue virus (DENV) infections play a role in the cycling pattern of dengue outbreaks. These findings add a new dimension to the continually evolving search for effective prevention strategies in dengue. Disappointing outcomes of clinical trials in anti-dengue modalities have become commonplace. These failures may result from confounding variables and/or unresolved scientific issues that surround dengue, including the replication cycle of DENV in a natural setting, the target cells and reservoir for viral replication in vivo, and the effect of asymptomatic/persistent carriers in the dissemination of dengue. This article sets forth to address these issues using the most updated information available in the literature and to propose a novel antiviral strategy for the prevention and control of dengue.

原文English
頁(從 - 到)97-108
頁數12
期刊Current Opinion in Virology
18
DOIs
出版狀態Published - 2016 六月 1

All Science Journal Classification (ASJC) codes

  • Virology

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