Novel role of mfd: Effects on stationary-phase mutagenesis in Bacillus subtilis

Christian Ross, Christine Pybus, Mario Pedraza-Reyes, Huang Mo Sung, Ronald E. Yasbin, Eduardo Robleto

研究成果: Article同行評審

47 引文 斯高帕斯(Scopus)

摘要

Previously, using a chromosomal reversion assay system, we established that an adaptive mutagenic process occurs in nongrowing Bacillus subtilis cells under stress, and we demonstrated that multiple mechanisms are involved in generating these mutations (41, 43). In an attempt to delineate how these mutations are generated, we began an investigation into whether or not transcription and transcription-associated proteins influence adaptive mutagenesis. In B. subtilis, the Mfd protein (transcription repair coupling factor) facilitates removal of RNA polymerase stalled at transcriptional blockages and recruitment of repair proteins to DNA lesions on the transcribed strand. Here we demonstrate that the loss of Mfd has a depressive effect on stationary-phase mutagenesis. An association between Mfd mutagenesis and aspects of transcription is discussed.

原文English
頁(從 - 到)7512-7520
頁數9
期刊Journal of Bacteriology
188
發行號21
DOIs
出版狀態Published - 2006 十一月

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Molecular Biology

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