Novel temperature based technique for measurement of endothelial dysfunction

Nachiket Kharalkar, Jonathan W. Valvano, Morteza Naghavi, Chia Ling Wei

研究成果: Conference article

4 引文 (Scopus)

摘要

The endothelial cells, which form the inner lining of the arteries, respond to changes in pressure by producing nitric oxide (NO) which in turn causes vasodilation. The normal functioning of the endothelium is hampered in certain cardiovascular diseases. Various methods have been developed to non-invasively determine the endothelial dysfunction (EDF). We propose to measure the EDF by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region. We created reactive hyperemia by occluding the arm by blood pressure cuff at about 200 mmHg for 5 minutes, and then suddenly released the pressure. Using a computer-based data acquisition system, the temperature variations of the distal palmer pad/middle finger, during the entire procedure were continuously monitored. Initial studies have indicated that there is significant increase in the rate of rise as compared to rate of fall of temperature (mean increase = 117%, standard deviation = 50%). Our goal is to non-invasively predict EDF from the temperature technique.

原文English
頁(從 - 到)308-311
頁數4
期刊Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
1
出版狀態Published - 2003 十二月 1
事件A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
持續時間: 2003 九月 172003 九月 21

指紋

Temperature
Hyperemia
Arm
Pressure
Endothelial cells
Blood pressure
Nitric oxide
Linings
Information Systems
Vasodilation
Fingers
Endothelium
Data acquisition
Nitric Oxide
Cardiovascular Diseases
Endothelial Cells
Hand
Arteries
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

引用此文

@article{a5dac45add674d03a2fe865f3a1bae58,
title = "Novel temperature based technique for measurement of endothelial dysfunction",
abstract = "The endothelial cells, which form the inner lining of the arteries, respond to changes in pressure by producing nitric oxide (NO) which in turn causes vasodilation. The normal functioning of the endothelium is hampered in certain cardiovascular diseases. Various methods have been developed to non-invasively determine the endothelial dysfunction (EDF). We propose to measure the EDF by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region. We created reactive hyperemia by occluding the arm by blood pressure cuff at about 200 mmHg for 5 minutes, and then suddenly released the pressure. Using a computer-based data acquisition system, the temperature variations of the distal palmer pad/middle finger, during the entire procedure were continuously monitored. Initial studies have indicated that there is significant increase in the rate of rise as compared to rate of fall of temperature (mean increase = 117{\%}, standard deviation = 50{\%}). Our goal is to non-invasively predict EDF from the temperature technique.",
author = "Nachiket Kharalkar and Valvano, {Jonathan W.} and Morteza Naghavi and Wei, {Chia Ling}",
year = "2003",
month = "12",
day = "1",
language = "English",
volume = "1",
pages = "308--311",
journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
issn = "1557-170X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

Novel temperature based technique for measurement of endothelial dysfunction. / Kharalkar, Nachiket; Valvano, Jonathan W.; Naghavi, Morteza; Wei, Chia Ling.

於: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 卷 1, 01.12.2003, p. 308-311.

研究成果: Conference article

TY - JOUR

T1 - Novel temperature based technique for measurement of endothelial dysfunction

AU - Kharalkar, Nachiket

AU - Valvano, Jonathan W.

AU - Naghavi, Morteza

AU - Wei, Chia Ling

PY - 2003/12/1

Y1 - 2003/12/1

N2 - The endothelial cells, which form the inner lining of the arteries, respond to changes in pressure by producing nitric oxide (NO) which in turn causes vasodilation. The normal functioning of the endothelium is hampered in certain cardiovascular diseases. Various methods have been developed to non-invasively determine the endothelial dysfunction (EDF). We propose to measure the EDF by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region. We created reactive hyperemia by occluding the arm by blood pressure cuff at about 200 mmHg for 5 minutes, and then suddenly released the pressure. Using a computer-based data acquisition system, the temperature variations of the distal palmer pad/middle finger, during the entire procedure were continuously monitored. Initial studies have indicated that there is significant increase in the rate of rise as compared to rate of fall of temperature (mean increase = 117%, standard deviation = 50%). Our goal is to non-invasively predict EDF from the temperature technique.

AB - The endothelial cells, which form the inner lining of the arteries, respond to changes in pressure by producing nitric oxide (NO) which in turn causes vasodilation. The normal functioning of the endothelium is hampered in certain cardiovascular diseases. Various methods have been developed to non-invasively determine the endothelial dysfunction (EDF). We propose to measure the EDF by causing reactive hyperemia in the arm and measuring the temperature variations of the hand region. We created reactive hyperemia by occluding the arm by blood pressure cuff at about 200 mmHg for 5 minutes, and then suddenly released the pressure. Using a computer-based data acquisition system, the temperature variations of the distal palmer pad/middle finger, during the entire procedure were continuously monitored. Initial studies have indicated that there is significant increase in the rate of rise as compared to rate of fall of temperature (mean increase = 117%, standard deviation = 50%). Our goal is to non-invasively predict EDF from the temperature technique.

UR - http://www.scopus.com/inward/record.url?scp=1542332735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542332735&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:1542332735

VL - 1

SP - 308

EP - 311

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SN - 1557-170X

ER -