NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds

Guan Han Lu, Tzu Chia Huang, Hsiao Chin Hsueh, Shin Cherng Yang, Ting Wei Cho, Ho Hsuan Chou

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

A novel universalN-transfer reagent for direct and effective transformation of α-amino ketones, acetamides, and esters to the corresponding α-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of α-substituted-α-diazo carbonyl compounds from α-amino acid derivatives but also permits preparation of α-diazo dipeptides fromN-terminal dipeptides (32 examples, up to 91%).

原文English
頁(從 - 到)4839-4842
頁數4
期刊Chemical Communications
57
發行號39
DOIs
出版狀態Published - 2021 5月 14

All Science Journal Classification (ASJC) codes

  • 催化
  • 電子、光磁材料
  • 陶瓷和複合材料
  • 一般化學
  • 表面、塗料和薄膜
  • 金屬和合金
  • 材料化學

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