Nuclear hormone receptors in podocytes

Simran Khurana, Leslie A. Bruggeman, Hung Ying Kao

研究成果: Review article同行評審

13 引文 斯高帕斯(Scopus)

摘要

Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.

原文English
文章編號33
期刊Cell and Bioscience
2
發行號1
DOIs
出版狀態Published - 2012 九月 20

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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