Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

Laszlo Nagy, Hung Ying Kao, Debabrata Chakravarti, Richard J. Lin, Christian A. Hassig, Donald E. Ayer, Stuart L. Schreiber, Ronald M. Evans

研究成果: Article同行評審

1073 引文 斯高帕斯(Scopus)

摘要

The transcriptional corepressors SMRT and N-CoR function as silencing mediators for retinoid and thyroid hormone receptors. Here we show that SMRT and N-CoR directly interact with mSin3A, a corepressor for the Mad-Max heterodimer and a homolog of the yeast global-transcriptional repressor Sin3p. In addition, we demonstrate that the recently characterized histone deacetylase 1 (HDAC1) interacts with Sin3A and SMRT to form a multisubunit repressor complex. Consistent with this model, we find that HDAC inhibitors synergize with retinoic acid to stimulate hormone-responsive genes and differentiation of myeloid leukemia (HL-60) cells. This work establishes a convergence of repression pathways for bHLH-Zip proteins and nuclear receptors and suggests this type of regulation may be more widely conserved than previously suspected.

原文English
頁(從 - 到)373-380
頁數8
期刊Cell
89
發行號3
DOIs
出版狀態Published - 1997 五月 2

All Science Journal Classification (ASJC) codes

  • 生物化學、遺傳與分子生物學 (全部)

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