Nuclei location enhancement based on improved efficient ellipse hough transform for third harmonic generation microscopy imaging

Yi Hsuan Chou, Shi Yu Hung, Gwo-Giun Lee, Wei Hung Weng, Yi Hua Liao, Chi Kung Sun, Han Ting Shih

研究成果: Conference contribution

摘要

Instead of conventional manual cell segmentation, this paper introduces a computer-Aided diagnosis protocol based on non-invasive in vivo virtual biopsy, third harmonic generation (THG) microscopy, which provides consistency and prompt suggestions for immediate clinical decisions without pain to patients. Specifically, we present a nuclei location re-inspection mechanism using enhanced efficient ellipse Hough transform with labeling and weighting information building upon previous watershed-based nuclei segmentation. This transform approach cautiously identifies nuclei location by considering not only staining intensity, but also examine shape feature to enhance the accuracy of nuclei recognition. The current approach has been implemented and tested on about 400 THG images from 25 healthy volunteers, and the receiver operating characteristic (ROC) curve has demonstrated the better performance of decreased false positive rate and increased true positive rate as compared to other nuclei location detection algorithms.

原文English
主出版物標題2015 IEEE China Summit and International Conference on Signal and Information Processing, ChinaSIP 2015 - Proceedings
發行者Institute of Electrical and Electronics Engineers Inc.
頁面807-811
頁數5
ISBN(電子)9781479919482
DOIs
出版狀態Published - 2015 八月 31
事件IEEE China Summit and International Conference on Signal and Information Processing, ChinaSIP 2015 - Chengdu, China
持續時間: 2015 七月 122015 七月 15

出版系列

名字2015 IEEE China Summit and International Conference on Signal and Information Processing, ChinaSIP 2015 - Proceedings

Other

OtherIEEE China Summit and International Conference on Signal and Information Processing, ChinaSIP 2015
國家China
城市Chengdu
期間15-07-1215-07-15

    指紋

All Science Journal Classification (ASJC) codes

  • Information Systems
  • Signal Processing

引用此

Chou, Y. H., Hung, S. Y., Lee, G-G., Weng, W. H., Liao, Y. H., Sun, C. K., & Shih, H. T. (2015). Nuclei location enhancement based on improved efficient ellipse hough transform for third harmonic generation microscopy imaging. 於 2015 IEEE China Summit and International Conference on Signal and Information Processing, ChinaSIP 2015 - Proceedings (頁 807-811). [7230516] (2015 IEEE China Summit and International Conference on Signal and Information Processing, ChinaSIP 2015 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/ChinaSIP.2015.7230516