Obesity and overweight in patients with hemophilia: Prevalence by age, clinical correlates, and impact on joint bleeding

Chia Yau Chang, Tsung Ying Li, Shin Nan Cheng, Ru Yu Pan, Chao-Neng Cheng, Hung Jung Wang, Shu Hsia Hu, Yeu Chin Chen

研究成果: Article

摘要

Background: The prevalence of obesity in patients with hemophilia (PWH) varies among different ethnicities, and its influence on joint bleeding and hemophilic arthropathy has not been studied in Taiwan population. We explored the prevalence and clinical correlates of obesity and the impact of body mass index (BMI) on annual joint bleeding rate (AJBR) and hemophilic arthropathy in PWH in Taiwan. Methods: We retrospectively collected clinical information on 140 severe/40 moderate PWH from 2006 to 2014. The patients’ median age was 31.5 years, ranged from 6 to 73 years. Their BMI, 6 index joints score by Pettersson scoring, AJBR, and other clinical data were analyzed. Results: The prevalence of overweight and obesity by age group was 7.1% in PWH aged ≤10 years, and rapidly increased to 34.5% in PWH aged 11 to 18 years, 46.7% in PWH aged 18 to 29 years, 61.8% in PWH aged 30 to 39 years, 60.6% in PWH aged 40 to 49 years, and 48% in PWH aged ≥50 years, respectively. Two peak rates were 72.7% in PWH aged 35 to 44 years and 66.7% in PWH aged >65 years. Age, HCV infection, knee score, elbow score, and total 6 index joints scores were found to correlate positively with BMI. However, subtype and severity of hemophilia, ankle scores, HBV and HIV infection did not correlate with BMI. Finally, BMI was found to correlate positively with AJBR in both adult and pediatric PWH. Conclusion: The prevalence of overweight and obesity in adolescent and adult PWH was higher than those in the general male population in Taiwan, which rapidly increased with age to peak in PWH aged 35 to 44 years and >65 years. High index joint score, with the exception of ankle scores, positively correlated with high BMI. Further, BMI and obesity also had positive correlation with AJBR in PWH. To our knowledge, this is the first study examining these associations in PWH in Taiwan.

原文English
頁(從 - 到)289-294
頁數6
期刊Journal of the Chinese Medical Association
82
發行號4
DOIs
出版狀態Published - 2019 一月 1

指紋

Hemophilia A
Obesity
Joints
Hemorrhage
Body Mass Index
Taiwan
Joint Diseases
Ankle
Pediatric Obesity
Elbow

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

Chang, Chia Yau ; Li, Tsung Ying ; Cheng, Shin Nan ; Pan, Ru Yu ; Cheng, Chao-Neng ; Wang, Hung Jung ; Hu, Shu Hsia ; Chen, Yeu Chin. / Obesity and overweight in patients with hemophilia : Prevalence by age, clinical correlates, and impact on joint bleeding. 於: Journal of the Chinese Medical Association. 2019 ; 卷 82, 編號 4. 頁 289-294.
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title = "Obesity and overweight in patients with hemophilia: Prevalence by age, clinical correlates, and impact on joint bleeding",
abstract = "Background: The prevalence of obesity in patients with hemophilia (PWH) varies among different ethnicities, and its influence on joint bleeding and hemophilic arthropathy has not been studied in Taiwan population. We explored the prevalence and clinical correlates of obesity and the impact of body mass index (BMI) on annual joint bleeding rate (AJBR) and hemophilic arthropathy in PWH in Taiwan. Methods: We retrospectively collected clinical information on 140 severe/40 moderate PWH from 2006 to 2014. The patients’ median age was 31.5 years, ranged from 6 to 73 years. Their BMI, 6 index joints score by Pettersson scoring, AJBR, and other clinical data were analyzed. Results: The prevalence of overweight and obesity by age group was 7.1{\%} in PWH aged ≤10 years, and rapidly increased to 34.5{\%} in PWH aged 11 to 18 years, 46.7{\%} in PWH aged 18 to 29 years, 61.8{\%} in PWH aged 30 to 39 years, 60.6{\%} in PWH aged 40 to 49 years, and 48{\%} in PWH aged ≥50 years, respectively. Two peak rates were 72.7{\%} in PWH aged 35 to 44 years and 66.7{\%} in PWH aged >65 years. Age, HCV infection, knee score, elbow score, and total 6 index joints scores were found to correlate positively with BMI. However, subtype and severity of hemophilia, ankle scores, HBV and HIV infection did not correlate with BMI. Finally, BMI was found to correlate positively with AJBR in both adult and pediatric PWH. Conclusion: The prevalence of overweight and obesity in adolescent and adult PWH was higher than those in the general male population in Taiwan, which rapidly increased with age to peak in PWH aged 35 to 44 years and >65 years. High index joint score, with the exception of ankle scores, positively correlated with high BMI. Further, BMI and obesity also had positive correlation with AJBR in PWH. To our knowledge, this is the first study examining these associations in PWH in Taiwan.",
author = "Chang, {Chia Yau} and Li, {Tsung Ying} and Cheng, {Shin Nan} and Pan, {Ru Yu} and Chao-Neng Cheng and Wang, {Hung Jung} and Hu, {Shu Hsia} and Chen, {Yeu Chin}",
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Obesity and overweight in patients with hemophilia : Prevalence by age, clinical correlates, and impact on joint bleeding. / Chang, Chia Yau; Li, Tsung Ying; Cheng, Shin Nan; Pan, Ru Yu; Cheng, Chao-Neng; Wang, Hung Jung; Hu, Shu Hsia; Chen, Yeu Chin.

於: Journal of the Chinese Medical Association, 卷 82, 編號 4, 01.01.2019, p. 289-294.

研究成果: Article

TY - JOUR

T1 - Obesity and overweight in patients with hemophilia

T2 - Prevalence by age, clinical correlates, and impact on joint bleeding

AU - Chang, Chia Yau

AU - Li, Tsung Ying

AU - Cheng, Shin Nan

AU - Pan, Ru Yu

AU - Cheng, Chao-Neng

AU - Wang, Hung Jung

AU - Hu, Shu Hsia

AU - Chen, Yeu Chin

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The prevalence of obesity in patients with hemophilia (PWH) varies among different ethnicities, and its influence on joint bleeding and hemophilic arthropathy has not been studied in Taiwan population. We explored the prevalence and clinical correlates of obesity and the impact of body mass index (BMI) on annual joint bleeding rate (AJBR) and hemophilic arthropathy in PWH in Taiwan. Methods: We retrospectively collected clinical information on 140 severe/40 moderate PWH from 2006 to 2014. The patients’ median age was 31.5 years, ranged from 6 to 73 years. Their BMI, 6 index joints score by Pettersson scoring, AJBR, and other clinical data were analyzed. Results: The prevalence of overweight and obesity by age group was 7.1% in PWH aged ≤10 years, and rapidly increased to 34.5% in PWH aged 11 to 18 years, 46.7% in PWH aged 18 to 29 years, 61.8% in PWH aged 30 to 39 years, 60.6% in PWH aged 40 to 49 years, and 48% in PWH aged ≥50 years, respectively. Two peak rates were 72.7% in PWH aged 35 to 44 years and 66.7% in PWH aged >65 years. Age, HCV infection, knee score, elbow score, and total 6 index joints scores were found to correlate positively with BMI. However, subtype and severity of hemophilia, ankle scores, HBV and HIV infection did not correlate with BMI. Finally, BMI was found to correlate positively with AJBR in both adult and pediatric PWH. Conclusion: The prevalence of overweight and obesity in adolescent and adult PWH was higher than those in the general male population in Taiwan, which rapidly increased with age to peak in PWH aged 35 to 44 years and >65 years. High index joint score, with the exception of ankle scores, positively correlated with high BMI. Further, BMI and obesity also had positive correlation with AJBR in PWH. To our knowledge, this is the first study examining these associations in PWH in Taiwan.

AB - Background: The prevalence of obesity in patients with hemophilia (PWH) varies among different ethnicities, and its influence on joint bleeding and hemophilic arthropathy has not been studied in Taiwan population. We explored the prevalence and clinical correlates of obesity and the impact of body mass index (BMI) on annual joint bleeding rate (AJBR) and hemophilic arthropathy in PWH in Taiwan. Methods: We retrospectively collected clinical information on 140 severe/40 moderate PWH from 2006 to 2014. The patients’ median age was 31.5 years, ranged from 6 to 73 years. Their BMI, 6 index joints score by Pettersson scoring, AJBR, and other clinical data were analyzed. Results: The prevalence of overweight and obesity by age group was 7.1% in PWH aged ≤10 years, and rapidly increased to 34.5% in PWH aged 11 to 18 years, 46.7% in PWH aged 18 to 29 years, 61.8% in PWH aged 30 to 39 years, 60.6% in PWH aged 40 to 49 years, and 48% in PWH aged ≥50 years, respectively. Two peak rates were 72.7% in PWH aged 35 to 44 years and 66.7% in PWH aged >65 years. Age, HCV infection, knee score, elbow score, and total 6 index joints scores were found to correlate positively with BMI. However, subtype and severity of hemophilia, ankle scores, HBV and HIV infection did not correlate with BMI. Finally, BMI was found to correlate positively with AJBR in both adult and pediatric PWH. Conclusion: The prevalence of overweight and obesity in adolescent and adult PWH was higher than those in the general male population in Taiwan, which rapidly increased with age to peak in PWH aged 35 to 44 years and >65 years. High index joint score, with the exception of ankle scores, positively correlated with high BMI. Further, BMI and obesity also had positive correlation with AJBR in PWH. To our knowledge, this is the first study examining these associations in PWH in Taiwan.

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