Oleic acid activates MMPs up-regulation through SIRT1/PPAR-γ inhibition: A probable linkage between obesity and coronary arterial disease

Shih Hung Chan, Pei Ming Chu, Chung Lan Kao, Yung Hsin Cheng, Ching Hsia Hung, Kun Ling Tsai

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Obesity is positively related to the growing prevalence of coronary arterial disease (CAD). It is well established in terms of the plasma concentrations of free fatty acid (FFA) that are up-regulated in cases associating with obesity. Oleic acid (OA) is known as the most abundant monounsaturated fatty acid in the human circulatory system. Several pro-atherosclerotic responses of OA have been established. Sirtuin 1 (SIRT1) acts as a key role in regulating the normal physical function in smooth muscle cells (SMCs). SIRT1 activation is developed as a novel approach to delay the progression of atherosclerotic injuries. However, the mechanism is still unclear as to whether OA affects SIRT1 expression and its activity in SMCs. We confirmed that OA treatment represses SIRT1 and peroxisome proliferator-activated receptors-γ levels in SMCs. Moreover, OA enhances by transforming the growth factor-β1 (TGF-β1) release via activation of NF-κB. OA causes NO production by inducing the inducible nitric oxide synthase overexpression, thereby promoting the secretions of matrix metalloproteinases-1 (MMP-1) and MMP-3. Overall, we suggested that OA enhances MMPs activation through SIRT1 down-regulation. Therefore, our findings might provide a novel route for developing new therapeutic treatments for FFAs-related CADs.

原文English
頁(從 - 到)217-225
頁數9
期刊Journal of biochemistry
160
發行號4
DOIs
出版狀態Published - 2016 10月 1

All Science Journal Classification (ASJC) codes

  • 生物化學
  • 分子生物學

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