Oligonucleotides-assembled au nanorod-assisted cancer photothermal ablation and combination chemotherapy with targeted dual-drug delivery of doxorubicin and cisplatin prodrug

Vijayakumar Shanmugam, Yi Hsin Chien, Yu Sheng Cheng, Tzu Yu Liu, Chih Chia Huang, Chia Hao Su, Yu Sen Chen, Umesh Kumar, Hua Fen Hsu, Chen Sheng Yeh

研究成果: Article同行評審

72 引文 斯高帕斯(Scopus)

摘要

External stimuli responsive dual drugs carrier was synthesized with Au nanorods (NRs) as the platform. On Au NRs, single stranded DNAs were assembled using 5′ thiol end. Following this, complementary DNA (cDNA) strands were hybridized. This hybridized double stranded DNA facilitated doxorubicin (Dox) intercalation into the duplexes. The cDNA designed with the 5′ amine functional group assisted to tether platinum [Pt(IV)] prodrugs by establishing amide bond with the acid group at the axial ligand. The other axial acid group in Pt(IV) prodrugs was conjugated with the folic acid (FA) to target folate receptors overexpressed in the cancer cells. This targeting vehicle provided remote-controlled delivery of this high toxic cargo cocktail at the tumor site, ensuring extra specificity that can avoid acute toxicity, where release of Dox and Pt(IV) was achieved upon NIR 808 nm diode laser irradiation. The dehybridization set the Dox free to bind the cell nucleus and cellular reductants reduced Pt(IV) to yield toxic Pt(II), becoming an active drug. The in vitro and in vivo studies revealed that this external stimulus responsive combination drug delivery was significantly effective.

原文English
頁(從 - 到)4382-4393
頁數12
期刊ACS Applied Materials and Interfaces
6
發行號6
DOIs
出版狀態Published - 2014 3月 26

All Science Journal Classification (ASJC) codes

  • 一般材料科學

指紋

深入研究「Oligonucleotides-assembled au nanorod-assisted cancer photothermal ablation and combination chemotherapy with targeted dual-drug delivery of doxorubicin and cisplatin prodrug」主題。共同形成了獨特的指紋。

引用此