On-Chip HbA_1C detection utlizing a compact surface pla-smon grating sensor integrated on a microfldic system

Diabetes mellitus may cause serious complications, including arteriosclerosis, heart disease and kidney failure, and therefore requires routine monitoring. Increasing evidences show that the concentration of glycated hemoglobin (HbA_1c) can be utilized as a more reliable index for diagnosing and monitoring diabetes. In this study, we presented a new approach using HbA_1c-specific aptamers as recognition molecules due to its high affinity and specificity. Moreover, a compact, grating-based surface plasmon resonance sensor incorporated with a microfluidic system was proposed to implement a compact, non-contact optical detection scheme for measuring HbA_1c.