Once-daily vs. twice-daily intrapleural urokinase treatment of complicated parapneumonic effusion in paediatric patients: A randomised, prospective study

Jieh-Neng Wang, C. T. Yao, C. N. Yeh, Ching-Chuan Liu, M. H. Wu, H. Y. Chuang, Jing-Ming Wu

研究成果: Article

11 引文 (Scopus)

摘要

To evaluate the effective dose frequency (once daily vs. twice daily) of intrapleural urokinase treatment in children who required tube thoracostomy for drainage of a complicated parapneumonic effusion, we designed a randomised prospective study in a tertiary medical centre in Taiwan. From June 2002 to January 2005, 30 paediatric patients with complicated parapneumonic effusion who had received chest tube drainage were randomised 1:1 to the once-daily (urokinase 5000-6000IU/kg/dose) or twice-daily (urokinase 2500-3000IU/kg/dose) treatment. We compared clinical manifestations and outcomes in both groups. There were no differences in pleural effusion characteristics between the groups. Six patients had Streptococcus pneumoniae, one had Staphylococcus aureus, one had Group A Streptococcus, and 22 had unknown pathogens. There were no significant differences between the once- vs. twice-daily group in the amount of drained pleural fluid (564.9 ± 422.1ml vs. 560.5 ± 198.6ml, respectively), fever duration after chest tube insertion (4.3 ± 3.2 days vs. 5.3 ± 2.7 days), or total admission days (14.3 ± 3.9 days vs. 14.6 ± 3.0 days) (p > 0.05 for all). Only two patients (one in each group) required the surgery. Thus, we found that both once- and twice-daily administration of urokinase were similarly efficacious, and resulted in good clinical outcomes. Both obviated the need for surgery in most (93%) cases of pneumonia with complicated parapneumonic effusion in this series. A larger, multicentre study is necessary to verify our findings.

原文English
頁(從 - 到)1225-1230
頁數6
期刊International Journal of Clinical Practice
60
發行號10
DOIs
出版狀態Published - 2006 十月 1

指紋

Urokinase-Type Plasminogen Activator
Prospective Studies
Pediatrics
Chest Tubes
Drainage
Thoracostomy
Pleural Effusion
Therapeutics
Streptococcus pneumoniae
Streptococcus
Taiwan
Multicenter Studies
Staphylococcus aureus
Pneumonia
Fever

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

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title = "Once-daily vs. twice-daily intrapleural urokinase treatment of complicated parapneumonic effusion in paediatric patients: A randomised, prospective study",
abstract = "To evaluate the effective dose frequency (once daily vs. twice daily) of intrapleural urokinase treatment in children who required tube thoracostomy for drainage of a complicated parapneumonic effusion, we designed a randomised prospective study in a tertiary medical centre in Taiwan. From June 2002 to January 2005, 30 paediatric patients with complicated parapneumonic effusion who had received chest tube drainage were randomised 1:1 to the once-daily (urokinase 5000-6000IU/kg/dose) or twice-daily (urokinase 2500-3000IU/kg/dose) treatment. We compared clinical manifestations and outcomes in both groups. There were no differences in pleural effusion characteristics between the groups. Six patients had Streptococcus pneumoniae, one had Staphylococcus aureus, one had Group A Streptococcus, and 22 had unknown pathogens. There were no significant differences between the once- vs. twice-daily group in the amount of drained pleural fluid (564.9 ± 422.1ml vs. 560.5 ± 198.6ml, respectively), fever duration after chest tube insertion (4.3 ± 3.2 days vs. 5.3 ± 2.7 days), or total admission days (14.3 ± 3.9 days vs. 14.6 ± 3.0 days) (p > 0.05 for all). Only two patients (one in each group) required the surgery. Thus, we found that both once- and twice-daily administration of urokinase were similarly efficacious, and resulted in good clinical outcomes. Both obviated the need for surgery in most (93{\%}) cases of pneumonia with complicated parapneumonic effusion in this series. A larger, multicentre study is necessary to verify our findings.",
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T2 - A randomised, prospective study

AU - Wang, Jieh-Neng

AU - Yao, C. T.

AU - Yeh, C. N.

AU - Liu, Ching-Chuan

AU - Wu, M. H.

AU - Chuang, H. Y.

AU - Wu, Jing-Ming

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N2 - To evaluate the effective dose frequency (once daily vs. twice daily) of intrapleural urokinase treatment in children who required tube thoracostomy for drainage of a complicated parapneumonic effusion, we designed a randomised prospective study in a tertiary medical centre in Taiwan. From June 2002 to January 2005, 30 paediatric patients with complicated parapneumonic effusion who had received chest tube drainage were randomised 1:1 to the once-daily (urokinase 5000-6000IU/kg/dose) or twice-daily (urokinase 2500-3000IU/kg/dose) treatment. We compared clinical manifestations and outcomes in both groups. There were no differences in pleural effusion characteristics between the groups. Six patients had Streptococcus pneumoniae, one had Staphylococcus aureus, one had Group A Streptococcus, and 22 had unknown pathogens. There were no significant differences between the once- vs. twice-daily group in the amount of drained pleural fluid (564.9 ± 422.1ml vs. 560.5 ± 198.6ml, respectively), fever duration after chest tube insertion (4.3 ± 3.2 days vs. 5.3 ± 2.7 days), or total admission days (14.3 ± 3.9 days vs. 14.6 ± 3.0 days) (p > 0.05 for all). Only two patients (one in each group) required the surgery. Thus, we found that both once- and twice-daily administration of urokinase were similarly efficacious, and resulted in good clinical outcomes. Both obviated the need for surgery in most (93%) cases of pneumonia with complicated parapneumonic effusion in this series. A larger, multicentre study is necessary to verify our findings.

AB - To evaluate the effective dose frequency (once daily vs. twice daily) of intrapleural urokinase treatment in children who required tube thoracostomy for drainage of a complicated parapneumonic effusion, we designed a randomised prospective study in a tertiary medical centre in Taiwan. From June 2002 to January 2005, 30 paediatric patients with complicated parapneumonic effusion who had received chest tube drainage were randomised 1:1 to the once-daily (urokinase 5000-6000IU/kg/dose) or twice-daily (urokinase 2500-3000IU/kg/dose) treatment. We compared clinical manifestations and outcomes in both groups. There were no differences in pleural effusion characteristics between the groups. Six patients had Streptococcus pneumoniae, one had Staphylococcus aureus, one had Group A Streptococcus, and 22 had unknown pathogens. There were no significant differences between the once- vs. twice-daily group in the amount of drained pleural fluid (564.9 ± 422.1ml vs. 560.5 ± 198.6ml, respectively), fever duration after chest tube insertion (4.3 ± 3.2 days vs. 5.3 ± 2.7 days), or total admission days (14.3 ± 3.9 days vs. 14.6 ± 3.0 days) (p > 0.05 for all). Only two patients (one in each group) required the surgery. Thus, we found that both once- and twice-daily administration of urokinase were similarly efficacious, and resulted in good clinical outcomes. Both obviated the need for surgery in most (93%) cases of pneumonia with complicated parapneumonic effusion in this series. A larger, multicentre study is necessary to verify our findings.

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