Optical Resolution of Some Racemates by HPLC Using Chiral Polymers Having (+)-5-Oxobornyl Moieties

Jui Hsiang Liu, Fu Jn Tsai

研究成果: Article同行評審

8 引文 斯高帕斯(Scopus)

摘要

To investigate the stereo coordination effect on the optical resolution, chiral monomer (+)-5-oxobornyl methacrylate (OBMA) was synthesized and then polymerized under various conditions. In this work, optical resolution was carried out in the presence of chiral polymers having (+)-5-oxobornyl moieties as chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC). Chiral polymer was immobilized on the surface of hydrophobic silica gel, and the chiral recognition ability of the chiral polymers was investigated. Effects of operation temperature and eluent flow rate on the chromatographic resolutions were investigated. The results of optical resolution were compared with those observed in our previous paper using chiral polymers (CSP-1 and CSP-2) having 2,3-dihydroxybornyl moieties as chiral stationary phases. It was found that the recognition ability of poly(OBMA) is greater than those of CSP-1 and CSP-2.

原文English
頁(從 - 到)677-682
頁數6
期刊Journal of Applied Polymer Science
72
發行號5
DOIs
出版狀態Published - 1999 五月 2

All Science Journal Classification (ASJC) codes

  • 化學 (全部)
  • 表面、塗料和薄膜
  • 聚合物和塑料
  • 材料化學

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