Optimal designs for asymmetric sigmoidal response curves in bioassays and immunoassays

Seung Won Hyun, Weng Kee Wong, Yarong Yang

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

The 5-parameter logistic (5PL) model is frequently used to model and analyze responses from bioassays and immunoassays which can be skewed. Various types of optimal experimental designs for 2, 3 and 4-parameter logistic models have been reported but not for the more complicated 5PL model. We construct different types of optimal designs for studying various features of the 5PL model and show that commonly used designs in bioassays and immunoassays are generally inefficient for statistical inference. To facilitate use of such designs in practice, we create a user-friendly software package to generate various tailor-made optimal designs for the 5PL model and evaluate robustness properties of a design under a variation of criteria, model forms and misspecification in the nominal values of the model parameters.

原文English
頁(從 - 到)421-436
頁數16
期刊Statistical Methods in Medical Research
29
發行號2
DOIs
出版狀態Published - 2020 2月 1

All Science Journal Classification (ASJC) codes

  • 流行病學
  • 統計與概率
  • 健康資訊管理

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