Optimal fuzzy sliding-mode control for bio-microfluidic manipulation

Yung Chiang Chung, Bor Jiunn Wen, Yu-Cheng Lin

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)


In biometric and biomedical applications, a special transporting mechanism must be designed for the micro total analysis system (μTAS) to move samples and reagents through the microchannels that connect the unit procedure components in the system. An important issue for this miniaturization and integration is the microfluid management technique, i.e., microfluid transportation, metering, and mixing. In view of this, an optimal fuzzy sliding-mode control (OFSMC) based on the 8051 microprocessor is designed and a complete microfluidic manipulated biochip system is implemented in this study, with a pneumatic pumping actuator, two feedback-signal photodiodes and flowmeters for better microfluidic management. This new technique successfully improved the efficiency of biochemical reaction by increasing the effective collision into the probe molecules as the target molecules flow back and forth. The new technique was used in DNA extraction. When the number of Escherichia coli cells was 2×102-104 in 25 μl of whole blood, the extraction efficiency of immobilized beads with solution flowing back and forth was 600-fold larger than that of free beads.

頁(從 - 到)1093-1105
期刊Control Engineering Practice
出版狀態Published - 2007 九月 1

All Science Journal Classification (ASJC) codes

  • 控制與系統工程
  • 電腦科學應用
  • 應用數學
  • 電氣與電子工程


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