Optimal Use of Perampanel in Elderly Asian Patients with Epilepsy: Expert Opinion

Chin Wei Huang, Kanokwan Boonyapisit, Suryani Gunadharma, Josephine Casanova-Gutierrez, Liri Jin, Dinesh Nayak, Naoki Akamatsu

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)


Managing epilepsy in the elderly remains complicated largely due to factors related to aging. In this population, management practices are increasingly shifting towards the use of newer-generation anti-seizure medications (ASMs) as they are generally associated with better tolerability and safety profiles than older ones. Perampanel is a new ASM with broad-spectrum efficacy and a favorable safety profile. However, because of the lack of information and experience in its use, the prescription of perampanel has not been optimized in the elderly in the real-world setting in Asia. A group of epilepsy experts across the region convened at a series of virtual meetings to share their experience and discuss recommendations on perampanel use in elderly patients, including dose optimization, considerations with treatment initiation, and strategies to manage adverse events and maximize tolerability. This article summarizes key clinical and real-world evidence for perampanel in the elderly and consolidates the experts’ opinions on optimizing perampanel use in elderly Asian patients with epilepsy, providing practical guidance for clinicians to address challenges related to treatment initiation and tolerance.

頁(從 - 到)825-832
期刊Therapeutics and Clinical Risk Management
出版狀態Published - 2022

All Science Journal Classification (ASJC) codes

  • 安全研究
  • 藥理學、毒理學和藥劑學 (全部)
  • 藥學(醫學)
  • 化學健康與安全


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