@inproceedings{176204a5146642bba9a65a091372f4ac,
title = "Optogenetic deconstructing the mechanism of neuroplasticity modulated by repetitive cortical stimulation",
abstract = "Cortical Theta burst stimulation (TBS) may modulate dopamine-dependent corticostriatal plasticity via long-term potentiation/depression (LTP/LTD) -like mechanism. This gives TBS a therapeutic potential for Parkinson{\textquoteright}s disease (PD) and other neural disorder. To unravel the mechanism beneath TBS-induced neuroplasticity, a novel optogenetic simulating method will be applied. CaMKII promoter-driven channelrhodopsin-2 (ChR2) will be delivered into glutamatergic pyramidal neuron in motor cortex by lentivirus. Under emitting of precisely controlled blue laser guided by fiber optics, the excitatory circuit in layer V will be elicited with TBS paradigm. Cortical excitabilities were examined by measuring optogenetic simulation-evoked potential and motor-evoked potential (MEP). In summary, we proposed a novel optical-TBS rodent model, which revealed the function role of glutamatergic circuit in motor plasticity.",
author = "Wu, {Chun Wei} and Hsieh, {Cho Han} and Chen, {Jia Jin Jason}",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing Switzerland 2015.; 1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 ; Conference date: 09-10-2014 Through 12-10-2014",
year = "2015",
doi = "10.1007/978-3-319-12262-5_72",
language = "English",
series = "IFMBE Proceedings",
publisher = "Springer Verlag",
pages = "260--263",
editor = "Fong-Chin Su and Ming-Long Yeh and Shyh-Hau Wang",
booktitle = "1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering",
address = "Germany",
}