Optogenetic deconstructing the mechanism of neuroplasticity modulated by repetitive cortical stimulation

Chun Wei Wu, Cho Han Hsieh, Jia Jin Jason Chen

研究成果: Conference contribution

摘要

Cortical Theta burst stimulation (TBS) may modulate dopamine-dependent corticostriatal plasticity via long-term potentiation/depression (LTP/LTD) -like mechanism. This gives TBS a therapeutic potential for Parkinson’s disease (PD) and other neural disorder. To unravel the mechanism beneath TBS-induced neuroplasticity, a novel optogenetic simulating method will be applied. CaMKII promoter-driven channelrhodopsin-2 (ChR2) will be delivered into glutamatergic pyramidal neuron in motor cortex by lentivirus. Under emitting of precisely controlled blue laser guided by fiber optics, the excitatory circuit in layer V will be elicited with TBS paradigm. Cortical excitabilities were examined by measuring optogenetic simulation-evoked potential and motor-evoked potential (MEP). In summary, we proposed a novel optical-TBS rodent model, which revealed the function role of glutamatergic circuit in motor plasticity.

原文English
主出版物標題1st Global Conference on Biomedical Engineering and 9th Asian-Pacific Conference on Medical and Biological Engineering
編輯Fong-Chin Su, Ming-Long Yeh, Shyh-Hau Wang
發行者Springer Verlag
頁面260-263
頁數4
ISBN(電子)9783319122618
出版狀態Published - 2015 1月 1
事件1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014 - Tainan, Taiwan
持續時間: 2014 10月 92014 10月 12

出版系列

名字IFMBE Proceedings
47
ISSN(列印)1680-0737
ISSN(電子)1433-9277

Other

Other1st Global Conference on Biomedical Engineering, GCBME 2014 and 9th Asian-Pacific Conference on Medical and Biological Engineering, APCMBE 2014
國家/地區Taiwan
城市Tainan
期間14-10-0914-10-12

All Science Journal Classification (ASJC) codes

  • 生物工程
  • 生物醫學工程

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