Oscillatory behavior of microbubbles impacts efficacy of cellular drug delivery

Yi Ju Ho, Ho Chun Chang, Chia Wei Lin, Ching Hsiang Fan, Yu Chun Lin, Kuo Chen Wei, Chih Kuang Yeh

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)


Drug-loaded microbubbles have been proven to be an effective strategy for non-invasive and local drug delivery when combined with ultrasound excitation for targeted drug release. Inertial cavitation is speculated to be a major mechanism for releasing drugs from drug-loaded microbubbles, but it results in lethal cellular pore damage that greatly limits its application. Thus, we investigated the cellular vesicle attachment and uptake to evaluate the efficiency of drug delivery by modulating the behaviors of targeted microbubble oscillation. The efficiency of vesicle attachment on the targeted cell membrane was 36.5 ± 15.9% and 3.8 ± 2.3% under stable and inertial cavitation, respectively. Further, stable cavitation enhanced cell permeability (26.8 ± 3.2%), maintained cell viability (90.8 ± 2.1%), and showed 7.9 ± 1.9-fold enhancement of in vivo vesicle release on tumor vessels. Therefore, our results reveal the ability to improve drug delivery via stable cavitation induced by targeted microbubbles. We propose that this strategy might be suitable for tissue repair or neuromodulation.

頁(從 - 到)316-327
期刊Journal of Controlled Release
出版狀態Published - 2021 五月 10

All Science Journal Classification (ASJC) codes

  • 藥學科學


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