Overexpression of HER-2/neu enhances the sensitivity of human bladder cancer cells to urinary isoflavones

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13 引文 斯高帕斯(Scopus)

摘要

Soybean foods have been suggested to be practical chemopreventives for human urinary tract cancers. Recently, we demonstrated that the co-operative action of isoflavones results in an increased dose-dependent growth inhibition and apoptosis than any single isoflavone compound. This study aimed to examine the potential of HER-2/neu as a biological target for soy isoflavones. The sensitivity of the bladder cancer cell lines (n = 7) to the isoflavones was inversely related to the amount of HER-2/neu expressed. By using HER-2/neu transfection experiments, all three stable transfectants showed a significant growth inhibition by the isoflavone mixture at concentrations attainable in normal adult urine. An increased inhibition of tyrosine phosphorylation of proteins immunoprecipitated by HER-2/Neu was observed in the neu-transfectants compared with controls. The results of this study suggest that HER-2/neu may be a practical biochemical target for urinary isoflavones in vivo.

原文English
頁(從 - 到)1413-1418
頁數6
期刊European Journal of Cancer
37
發行號11
DOIs
出版狀態Published - 2001

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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