Computer-integrated manufacturing (CIM) has attracted many interests both in academic research and in practical implementation. Design and implementation of a CIM project involves the massive modeling, simulation, and verification of production operations, machines, and operators. Overhead hoist transporter (OHT) is one of the effective tools for the automated material handling system that often applied in CIM projects to ultimate the utilization of footprint of a factory. This paper presents a case study for the OHT system design in a CIM project for automated food processing production line. The effectiveness of the number of OHTs installed for the production line and the proper operation scenarios for different production planning are studied. Modeling and simulation results suggest an efficient OHT system design for the CIM project.