TY - GEN
T1 - Oxidized LDL as an effective anti-cancer bio nanoparticle
AU - Wang, Pei Wen
AU - Chen, Chu Huang
AU - Shieh, Dar Bin
PY - 2008/11/10
Y1 - 2008/11/10
N2 - Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.
AB - Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.
UR - http://www.scopus.com/inward/record.url?scp=55349098250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55349098250&partnerID=8YFLogxK
U2 - 10.1109/NANO.2008.203
DO - 10.1109/NANO.2008.203
M3 - Conference contribution
AN - SCOPUS:55349098250
SN - 9781424421046
T3 - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
SP - 673
EP - 674
BT - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
T2 - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
Y2 - 18 August 2008 through 21 August 2008
ER -