Oxidized LDL as an effective anti-cancer bio nanoparticle

Pei Wen Wang; Chu Huang Chen; Dar Bin Shieh

doi:10.1109/NANO.2008.203

Oxidized LDL as an effective anti-cancer bio nanoparticle

Pei Wen Wang, Chu Huang Chen, Dar Bin Shieh

研究成果: Conference contribution

摘要

Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.

原文	English
主出版物標題	2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
頁面	673-674
頁數	2
DOIs	https://doi.org/10.1109/NANO.2008.203
出版狀態	Published - 2008 11月 10
事件	2008 8th IEEE Conference on Nanotechnology, IEEE-NANO - Arlington, TX, United States 持續時間: 2008 8月 18 → 2008 8月 21

出版系列

名字	2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

Other

Other	2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
國家/地區	United States
城市	Arlington, TX
期間	08-08-18 → 08-08-21

All Science Journal Classification (ASJC) codes

電氣與電子工程

UN SDG

此研究成果有助於以下永續發展目標

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10.1109/NANO.2008.203

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引用此

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title = "Oxidized LDL as an effective anti-cancer bio nanoparticle",

abstract = "Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.",

author = "Wang, {Pei Wen} and Chen, {Chu Huang} and Shieh, {Dar Bin}",

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doi = "10.1109/NANO.2008.203",

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N2 - Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.

AB - Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.

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DO - 10.1109/NANO.2008.203

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T3 - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

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T2 - 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

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ER -

Oxidized LDL as an effective anti-cancer bio nanoparticle

摘要

出版系列

Other

All Science Journal Classification (ASJC) codes

UN SDG

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