Oxidized LDL as an effective anti-cancer bio nanoparticle

Pei Wen Wang, Chu Huang Chen, Dar Bin Shieh

研究成果: Conference contribution

摘要

Low density lipoproteins are natural nanoparticles derived from lipid metabolism. Ox-LDLs are generated by LDLs ongoing auto-oxidation. It has been shown that oxLDL induced apoptosis of endothelial cells and is highly associated with arthrosclerosis and other cardiovascular diseases. Our study demonstrated ox-LDLs not only induce endothelial cell apoptosis but also promote tumor ceDs ongoing apoptosis. Measurement of mitochondrial membrane potential (ΔΨ) revealed a significant loss of the ΔΨ upon exposure to oxLDL and a dose dependency was observed. Further exploration to redirect oxLDL as an alternative cancer cell targeting chemotherapeutic agent and anti-cancer drug carrier could be a potential new therapeutic strategy.

原文English
主出版物標題2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
頁面673-674
頁數2
DOIs
出版狀態Published - 2008 十一月 10
事件2008 8th IEEE Conference on Nanotechnology, IEEE-NANO - Arlington, TX, United States
持續時間: 2008 八月 182008 八月 21

出版系列

名字2008 8th IEEE Conference on Nanotechnology, IEEE-NANO

Other

Other2008 8th IEEE Conference on Nanotechnology, IEEE-NANO
國家United States
城市Arlington, TX
期間08-08-1808-08-21

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering

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  • 引用此

    Wang, P. W., Chen, C. H., & Shieh, D. B. (2008). Oxidized LDL as an effective anti-cancer bio nanoparticle. 於 2008 8th IEEE Conference on Nanotechnology, IEEE-NANO (頁 673-674). [4617185] (2008 8th IEEE Conference on Nanotechnology, IEEE-NANO). https://doi.org/10.1109/NANO.2008.203