P300 waveform and dopamine transporter availability: A controlled EEG and SPECT study in medication-naive patients with schizophrenia and a meta-analysis

K. C. Chen, I. H. Lee, Y. K. Yang, S. Landau, W. H. Chang, P. S. Chen, R. B. Lu, A. S. David, E. Bramon

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16 引文 斯高帕斯(Scopus)

摘要

Background Reduced P300 event-related potential (ERP) amplitude and latency prolongation have been reported in patients with schizophrenia compared to healthy controls. However, the influence of antipsychotics (and dopamine) on ERP measures are poorly understood and medication confounding remains a possibility. Method We explored ERP differences between 36 drug-naive patients with schizophrenia and 138 healthy controls and examined whether P300 performance was related to dopamine transporter (DAT) availability, both without the confounding effects of medication. We also conducted a random effects meta-analysis of the available literature, synthesizing the results of three comparable published articles and our local study. Results No overall significant difference was found in mean P300 ERP between patients and controls in latency or in amplitude. There was a significant gender effect, with females showing greater P300 amplitude than males. A difference between patients and controls in P300 latency was evident with ageing, with latency increasing faster in patients. No effect of DAT availability on P300 latency or amplitude was detected. The meta-analysis computed the latency pooled standardized effect size (PSES; Cohen's d) of -0.13 and the amplitude PSES (Cohen's d) of 0.48, with patients showing a significant reduction in amplitude. Conclusions Our findings suggest the P300 ERP is not altered in the early stages of schizophrenia before medication is introduced, and the DAT availability does not influence the P300 ERP amplitude or latency. P300 ERP amplitude reduction could be an indicator of the progression of illness and chronicity.

原文English
頁(從 - 到)2151-2162
頁數12
期刊Psychological Medicine
44
發行號10
DOIs
出版狀態Published - 2014 7月

All Science Journal Classification (ASJC) codes

  • 應用心理學
  • 精神病學和心理健康

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