Painless skin electroporation as a novel way for insulin delivery

Tak Wah Wong, Tai Yu Chen, Chien Chun Huang, Jui Chen Tsai, Sek Wen Hui

研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)

摘要

Background: Rigorous research efforts have been undertaken worldwide to develop a needle-free insulin delivery for many decades with limited success. This translational study aims to deliver insulin through skin with painless electroporation. Methods: A recently designed microelectrode array was used to deliver insulin in mice with diabetes under electroporation conditions that are painless and harmless on human skin. Results: Under such condition, a therapeutic amount of insulin was delivered successfully through mouse skin. Electroporation alone increased insulin transport around 100-fold compared with passive diffusion. Increased skin temperature to 40°C for 20 min augmented insulin transport to 237-fold more than the control value. Repeated electroporation showed no harm on human skin. Conclusion: The results indicate the potential of painless delivery of insulin through human skin in future clinical practice.

原文English
頁(從 - 到)929-935
頁數7
期刊Diabetes Technology and Therapeutics
13
發行號9
DOIs
出版狀態Published - 2011 九月 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Medical Laboratory Technology

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