Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer

Nan Haw Chow, Paul Cairns, Claus F. Eisenberger, Mark P. Schoenberg, David C. Taylor, Jonathan I. Epstein, David Sidransky

研究成果: Article同行評審

82 引文 斯高帕斯(Scopus)

摘要

Papilloma and papillary hyperplasia (PH) have been proposed to be the putative precursor lesions of papillary transitional-cell carcinoma of the urinary bladder. We examined 15 PH lesions and 4 papillomas for loss of heterozygosity (LOH) at 17 microsatellite markers on 9 chromosomal arms. Eight of 15 (53%) PHs were clonal, demonstrating LOH of at least 1 microsatellite marker. In contrast, none of the papillomas showed any genetic changes among the markers tested. In PH, chromosomal arm 9q was the most frequently lost (4/15), followed by 9p and 18q (n = 2) and, less frequently, 8p, 10q, 11p and 17p (n = 1). Furthermore, 2 hyperplastic lesions demonstrated LOH at 9q only, confirming the notion that allelic loss on chromosomal arm 9q is among the earliest events in bladder-cancer progression. In 1 patient, identical LOH patterns were observed between PH and a recurrent transitional-cell carcinoma. Our molecular data demonstrate that at least a proportion of PHs represent pre-cancerous lesions of the bladder that subsequently progress to papillary bladder cancer. Moreover, chromosomal arm 9q may harbor a tumor-suppressor gene(s) inactivated in the earliest stages of human bladder tumorigenesis. (C) 2000 Wiley-Liss, Inc.

原文English
頁(從 - 到)514-518
頁數5
期刊International Journal of Cancer
89
發行號6
DOIs
出版狀態Published - 2000 十一月 20

All Science Journal Classification (ASJC) codes

  • 腫瘤科
  • 癌症研究

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