Paraneoplastic neurological disorders in children with benign ovarian tumors

Mei Hsin Hsu, Chao-Ching Huang, Pi Lien Hung, Hsiu Mei Huang, Li Tung Huang, Chao Cheng Huang, Jiunn Ming Sheen, Song Chei Huang, Ying Chao Chang

研究成果: Article

10 引文 斯高帕斯(Scopus)

摘要

Aim: Paraneoplastic neurological diseases (PND) are rare, but potentially treatable disorders. Paraneoplastic encephalitis is rapidly emerging as an important but likely under-recognized condition in children. The aim of this study was to assess the prevalence and spectrum of PND in children with benign ovary tumor and the long-term outcome. Patients and methods: We retrospectively reviewed the charts of all female patients below 18. years of age diagnosed with a benign ovarian tumor proven by pathology between January 1993 and December 2010. All the clinical symptoms developed within 5. years of tumor diagnosis and the related investigations were recorded. Results: There were total 133 children and adolescents with benign ovarian tumors, mostly mature teratoma. Six patients (4.5%) had neuropsychiatric manifestations and all but one were beyond age 10. years. The most common neuropsychiatric presentations were depression or low mood (84%), headache (50%), mutism (50%), hypoventilation (50%), seizures (30%), hallucination (30%), vomiting and hypersalivation (30%). Three patients (2.2%) had serious PND including acute disseminated encephalomyelitis in 1 and anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis in 2. Although all of three improved after tumor removal, one without immunotherapy had neurological sequelae and prolonged ICU stay. Conclusion: The prevalence of PND in benign ovary tumor is not so uncommon in children. It is important to survey ovary tumors in female adolescents with subacute presentation of multiple-level involvement of neuraxis where no clear alternate diagnosis is possible. Treatment of serious PND associated with ovary tumors should include immunotherapy in addition to tumor removal.

原文English
頁(從 - 到)248-253
頁數6
期刊Brain and Development
36
發行號3
DOIs
出版狀態Published - 2014 三月 1

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

指紋 深入研究「Paraneoplastic neurological disorders in children with benign ovarian tumors」主題。共同形成了獨特的指紋。

  • 引用此

    Hsu, M. H., Huang, C-C., Hung, P. L., Huang, H. M., Huang, L. T., Huang, C. C., Sheen, J. M., Huang, S. C., & Chang, Y. C. (2014). Paraneoplastic neurological disorders in children with benign ovarian tumors. Brain and Development, 36(3), 248-253. https://doi.org/10.1016/j.braindev.2013.04.009