Parathyroid storm: report of two cases

J. J. Huang, J. M. Sung, T. J. Wu, M. K. Ruaan, S. M. Huang, N. H. Chow

研究成果: Article

3 引文 (Scopus)

摘要

Parathyroid storm in patients with primary hyperparathyroidism has previously been described as hyperparathyroid crisis, parathyroid intoxication or acute hyperparathyroidism. Whatever the nomenclature, all emphasize the severity and urgency of this disease entity. Although fewer than 200 cases have been described since the first report by Dawson in 1932, it is generally agreed that parathyroid storm is more prevalent than commonly appreciated. The symptoms and signs of the syndrome are not only due to the hypercalcemia, but also to the toxic effects of the parathyroid hormone (PTH). Its wide, but nonspecific clinical presentations make it easily confused with other cardiovascular or renal diseases. The mortality rate in untreated cases of parathyroid storm is essentially 100%. With combined medical-surgical treatment, it is still reported to be as high as 40%. Two patients with parathyroid storm were encountered at our institute recently, they both presented with severe hypercalcemia, consciousness disturbance and acute renal failure. The serum level of the intact form of PTH (iPTH) in both patients was greater than 1,000 pg/mL. Case 1, a 63-year-old female, presented with hypercalcemic crisis. Initially, good responsiveness to a saline infusion, steroids and furosemide administration was noted. Unfortunately, she became comatous after fine-needle aspiration of the parathyroid tumor. The recurrent storm was refractory to medical therapy, but was treated successfully by surgical removal of the single adenoma. This is a rare reported case regarding a hyperparathyroid storm after fine-needle aspiration of a parathyroid adenoma.(ABSTRACT TRUNCATED AT 250 WORDS)

原文English
頁(從 - 到)S255-259
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
91 Suppl 3
出版狀態Published - 1992 九月

指紋

Hypercalcemia
Fine Needle Biopsy
Parathyroid Hormone
Parathyroid Neoplasms
Primary Hyperparathyroidism
Hyperparathyroidism
Poisons
Furosemide
Consciousness
Acute Kidney Injury
Terminology
Adenoma
Signs and Symptoms
Steroids
Kidney
Mortality
Therapeutics
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

Huang, J. J., Sung, J. M., Wu, T. J., Ruaan, M. K., Huang, S. M., & Chow, N. H. (1992). Parathyroid storm: report of two cases. Journal of the Formosan Medical Association = Taiwan yi zhi, 91 Suppl 3, S255-259.
Huang, J. J. ; Sung, J. M. ; Wu, T. J. ; Ruaan, M. K. ; Huang, S. M. ; Chow, N. H. / Parathyroid storm : report of two cases. 於: Journal of the Formosan Medical Association = Taiwan yi zhi. 1992 ; 卷 91 Suppl 3. 頁 S255-259.
@article{c7aef569d3a24a24a08724f0cd20c91e,
title = "Parathyroid storm: report of two cases",
abstract = "Parathyroid storm in patients with primary hyperparathyroidism has previously been described as hyperparathyroid crisis, parathyroid intoxication or acute hyperparathyroidism. Whatever the nomenclature, all emphasize the severity and urgency of this disease entity. Although fewer than 200 cases have been described since the first report by Dawson in 1932, it is generally agreed that parathyroid storm is more prevalent than commonly appreciated. The symptoms and signs of the syndrome are not only due to the hypercalcemia, but also to the toxic effects of the parathyroid hormone (PTH). Its wide, but nonspecific clinical presentations make it easily confused with other cardiovascular or renal diseases. The mortality rate in untreated cases of parathyroid storm is essentially 100{\%}. With combined medical-surgical treatment, it is still reported to be as high as 40{\%}. Two patients with parathyroid storm were encountered at our institute recently, they both presented with severe hypercalcemia, consciousness disturbance and acute renal failure. The serum level of the intact form of PTH (iPTH) in both patients was greater than 1,000 pg/mL. Case 1, a 63-year-old female, presented with hypercalcemic crisis. Initially, good responsiveness to a saline infusion, steroids and furosemide administration was noted. Unfortunately, she became comatous after fine-needle aspiration of the parathyroid tumor. The recurrent storm was refractory to medical therapy, but was treated successfully by surgical removal of the single adenoma. This is a rare reported case regarding a hyperparathyroid storm after fine-needle aspiration of a parathyroid adenoma.(ABSTRACT TRUNCATED AT 250 WORDS)",
author = "Huang, {J. J.} and Sung, {J. M.} and Wu, {T. J.} and Ruaan, {M. K.} and Huang, {S. M.} and Chow, {N. H.}",
year = "1992",
month = "9",
language = "English",
volume = "91 Suppl 3",
pages = "S255--259",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Excerpta Medica Asia Ltd.",

}

Huang, JJ, Sung, JM, Wu, TJ, Ruaan, MK, Huang, SM & Chow, NH 1992, 'Parathyroid storm: report of two cases', Journal of the Formosan Medical Association = Taiwan yi zhi, 卷 91 Suppl 3, 頁 S255-259.

Parathyroid storm : report of two cases. / Huang, J. J.; Sung, J. M.; Wu, T. J.; Ruaan, M. K.; Huang, S. M.; Chow, N. H.

於: Journal of the Formosan Medical Association = Taiwan yi zhi, 卷 91 Suppl 3, 09.1992, p. S255-259.

研究成果: Article

TY - JOUR

T1 - Parathyroid storm

T2 - report of two cases

AU - Huang, J. J.

AU - Sung, J. M.

AU - Wu, T. J.

AU - Ruaan, M. K.

AU - Huang, S. M.

AU - Chow, N. H.

PY - 1992/9

Y1 - 1992/9

N2 - Parathyroid storm in patients with primary hyperparathyroidism has previously been described as hyperparathyroid crisis, parathyroid intoxication or acute hyperparathyroidism. Whatever the nomenclature, all emphasize the severity and urgency of this disease entity. Although fewer than 200 cases have been described since the first report by Dawson in 1932, it is generally agreed that parathyroid storm is more prevalent than commonly appreciated. The symptoms and signs of the syndrome are not only due to the hypercalcemia, but also to the toxic effects of the parathyroid hormone (PTH). Its wide, but nonspecific clinical presentations make it easily confused with other cardiovascular or renal diseases. The mortality rate in untreated cases of parathyroid storm is essentially 100%. With combined medical-surgical treatment, it is still reported to be as high as 40%. Two patients with parathyroid storm were encountered at our institute recently, they both presented with severe hypercalcemia, consciousness disturbance and acute renal failure. The serum level of the intact form of PTH (iPTH) in both patients was greater than 1,000 pg/mL. Case 1, a 63-year-old female, presented with hypercalcemic crisis. Initially, good responsiveness to a saline infusion, steroids and furosemide administration was noted. Unfortunately, she became comatous after fine-needle aspiration of the parathyroid tumor. The recurrent storm was refractory to medical therapy, but was treated successfully by surgical removal of the single adenoma. This is a rare reported case regarding a hyperparathyroid storm after fine-needle aspiration of a parathyroid adenoma.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Parathyroid storm in patients with primary hyperparathyroidism has previously been described as hyperparathyroid crisis, parathyroid intoxication or acute hyperparathyroidism. Whatever the nomenclature, all emphasize the severity and urgency of this disease entity. Although fewer than 200 cases have been described since the first report by Dawson in 1932, it is generally agreed that parathyroid storm is more prevalent than commonly appreciated. The symptoms and signs of the syndrome are not only due to the hypercalcemia, but also to the toxic effects of the parathyroid hormone (PTH). Its wide, but nonspecific clinical presentations make it easily confused with other cardiovascular or renal diseases. The mortality rate in untreated cases of parathyroid storm is essentially 100%. With combined medical-surgical treatment, it is still reported to be as high as 40%. Two patients with parathyroid storm were encountered at our institute recently, they both presented with severe hypercalcemia, consciousness disturbance and acute renal failure. The serum level of the intact form of PTH (iPTH) in both patients was greater than 1,000 pg/mL. Case 1, a 63-year-old female, presented with hypercalcemic crisis. Initially, good responsiveness to a saline infusion, steroids and furosemide administration was noted. Unfortunately, she became comatous after fine-needle aspiration of the parathyroid tumor. The recurrent storm was refractory to medical therapy, but was treated successfully by surgical removal of the single adenoma. This is a rare reported case regarding a hyperparathyroid storm after fine-needle aspiration of a parathyroid adenoma.(ABSTRACT TRUNCATED AT 250 WORDS)

UR - http://www.scopus.com/inward/record.url?scp=0026922078&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026922078&partnerID=8YFLogxK

M3 - Article

C2 - 1362914

AN - SCOPUS:0026922078

VL - 91 Suppl 3

SP - S255-259

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

ER -