Pathogenesis of virus-associated human cancers: Epstein-Barr virus and hepatitis B virus as two examples

Kung-Chao Chang, Yao Chang, Lily Hui Ching Wang, Hung-Wen Tsai, Wen-Ya Huang, Ih Jen Su

研究成果: Review article

2 引文 (Scopus)

摘要

Virus-associated human cancers may exhibit two characteristic histopathologic features: (1) the inflammation-rich background as observed in Epstein-Barr virus-associated Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC); and (2) the characteristic nuclear morphology such as the Reed-Sternberg cells in HL. Besides, the hepatocytes of chronic hepatitis B virus (HBV) infection frequently exhibit characteristic ground glass hepatocytes, a phenomenon associated with endoplasmic reticulum stress response induced by the overloaded or malfolded HBV surface antigens. In this review, we explore specifically the pathogenesis of Epstein-Barr virus-associated HL and NPC, and HBV-associated hepatocellular carcinoma based on the observed histopathologic features. We propose that the retention of viral proteins induces inflammation, endoplasmic reticulum stress, and genomic instability in HL, NPC, and hepatocellular carcinoma, whereby the viral oncoproteins may play additional transactivational roles to induce host genes for transformation, invasion, and metastasis. Therapeutic implications based on the pathogenesis of virus-associated cancers are discussed.

原文English
頁(從 - 到)581-590
頁數10
期刊Journal of the Formosan Medical Association
113
發行號9
DOIs
出版狀態Published - 2014 一月 1

指紋

Human Herpesvirus 4
Hodgkin Disease
Hepatitis B virus
Viruses
Endoplasmic Reticulum Stress
Hepatocytes
Hepatocellular Carcinoma
Neoplasms
Reed-Sternberg Cells
Inflammation
Genomic Instability
Oncogene Proteins
Chronic Hepatitis B
Viral Proteins
Virus Diseases
Hepatitis B Surface Antigens
Glass
Neoplasm Metastasis
Genes
Nasopharyngeal carcinoma

All Science Journal Classification (ASJC) codes

  • Medicine(all)

引用此文

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title = "Pathogenesis of virus-associated human cancers: Epstein-Barr virus and hepatitis B virus as two examples",
abstract = "Virus-associated human cancers may exhibit two characteristic histopathologic features: (1) the inflammation-rich background as observed in Epstein-Barr virus-associated Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC); and (2) the characteristic nuclear morphology such as the Reed-Sternberg cells in HL. Besides, the hepatocytes of chronic hepatitis B virus (HBV) infection frequently exhibit characteristic ground glass hepatocytes, a phenomenon associated with endoplasmic reticulum stress response induced by the overloaded or malfolded HBV surface antigens. In this review, we explore specifically the pathogenesis of Epstein-Barr virus-associated HL and NPC, and HBV-associated hepatocellular carcinoma based on the observed histopathologic features. We propose that the retention of viral proteins induces inflammation, endoplasmic reticulum stress, and genomic instability in HL, NPC, and hepatocellular carcinoma, whereby the viral oncoproteins may play additional transactivational roles to induce host genes for transformation, invasion, and metastasis. Therapeutic implications based on the pathogenesis of virus-associated cancers are discussed.",
author = "Kung-Chao Chang and Yao Chang and Wang, {Lily Hui Ching} and Hung-Wen Tsai and Wen-Ya Huang and Su, {Ih Jen}",
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T1 - Pathogenesis of virus-associated human cancers

T2 - Epstein-Barr virus and hepatitis B virus as two examples

AU - Chang, Kung-Chao

AU - Chang, Yao

AU - Wang, Lily Hui Ching

AU - Tsai, Hung-Wen

AU - Huang, Wen-Ya

AU - Su, Ih Jen

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Virus-associated human cancers may exhibit two characteristic histopathologic features: (1) the inflammation-rich background as observed in Epstein-Barr virus-associated Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC); and (2) the characteristic nuclear morphology such as the Reed-Sternberg cells in HL. Besides, the hepatocytes of chronic hepatitis B virus (HBV) infection frequently exhibit characteristic ground glass hepatocytes, a phenomenon associated with endoplasmic reticulum stress response induced by the overloaded or malfolded HBV surface antigens. In this review, we explore specifically the pathogenesis of Epstein-Barr virus-associated HL and NPC, and HBV-associated hepatocellular carcinoma based on the observed histopathologic features. We propose that the retention of viral proteins induces inflammation, endoplasmic reticulum stress, and genomic instability in HL, NPC, and hepatocellular carcinoma, whereby the viral oncoproteins may play additional transactivational roles to induce host genes for transformation, invasion, and metastasis. Therapeutic implications based on the pathogenesis of virus-associated cancers are discussed.

AB - Virus-associated human cancers may exhibit two characteristic histopathologic features: (1) the inflammation-rich background as observed in Epstein-Barr virus-associated Hodgkin lymphoma (HL) and nasopharyngeal carcinoma (NPC); and (2) the characteristic nuclear morphology such as the Reed-Sternberg cells in HL. Besides, the hepatocytes of chronic hepatitis B virus (HBV) infection frequently exhibit characteristic ground glass hepatocytes, a phenomenon associated with endoplasmic reticulum stress response induced by the overloaded or malfolded HBV surface antigens. In this review, we explore specifically the pathogenesis of Epstein-Barr virus-associated HL and NPC, and HBV-associated hepatocellular carcinoma based on the observed histopathologic features. We propose that the retention of viral proteins induces inflammation, endoplasmic reticulum stress, and genomic instability in HL, NPC, and hepatocellular carcinoma, whereby the viral oncoproteins may play additional transactivational roles to induce host genes for transformation, invasion, and metastasis. Therapeutic implications based on the pathogenesis of virus-associated cancers are discussed.

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