TY - JOUR
T1 - PDGFRα-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia
AU - Tamai, Katsuto
AU - Yamazaki, Takehiko
AU - Chino, Takenao
AU - Ishii, Masaru
AU - Otsuru, Satoru
AU - Kikuchi, Yasushi
AU - Iinuma, Shin
AU - Saga, Kotaro
AU - Nimura, Keisuke
AU - Shimbo, Takashi
AU - Umegaki, Noriko
AU - Katayama, Ichiro
AU - Miyazaki, Jun Ichi
AU - Takeda, Junji
AU - McGrath, John A.
AU - Uitto, Jouni
AU - Kaneda, Yasufumi
PY - 2011/4/19
Y1 - 2011/4/19
N2 - The role of bone marrow cells in repairing ectodermal tissue, such as skin epidermis, is not clear. To explore this process further, this study examined a particular form of cutaneous repair, skin grafting. Grafting of full thickness wild-type mouse skin onto mice that had received a green fluorescent protein-bone marrow transplant after whole body irradiation led to an abundance of bone marrow-derived epithelial cells in follicular and interfollicular epidermis that persisted for at least 5 mo. The source of the epithelial progenitors was the nonhematopoietic, platelet-derived growth factor receptor α-positive (Lin-/PDGFRα+) bone marrow cell population. Skin grafts release high mobility group box 1 (HMGB1) in vitro and in vivo, which can mobilize the Lin-/PDGFRα+ cells from bone marrow to target the engrafted skin. These data provide unique insight into how skin grafts facilitate tissue repair and identify strategies germane to regenerative medicine for skin and, perhaps, other ectodermal defects or diseases.
AB - The role of bone marrow cells in repairing ectodermal tissue, such as skin epidermis, is not clear. To explore this process further, this study examined a particular form of cutaneous repair, skin grafting. Grafting of full thickness wild-type mouse skin onto mice that had received a green fluorescent protein-bone marrow transplant after whole body irradiation led to an abundance of bone marrow-derived epithelial cells in follicular and interfollicular epidermis that persisted for at least 5 mo. The source of the epithelial progenitors was the nonhematopoietic, platelet-derived growth factor receptor α-positive (Lin-/PDGFRα+) bone marrow cell population. Skin grafts release high mobility group box 1 (HMGB1) in vitro and in vivo, which can mobilize the Lin-/PDGFRα+ cells from bone marrow to target the engrafted skin. These data provide unique insight into how skin grafts facilitate tissue repair and identify strategies germane to regenerative medicine for skin and, perhaps, other ectodermal defects or diseases.
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U2 - 10.1073/pnas.1016753108
DO - 10.1073/pnas.1016753108
M3 - Article
C2 - 21464317
AN - SCOPUS:79955619770
SN - 0027-8424
VL - 108
SP - 6609
EP - 6614
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 16
ER -