Pharmacometrics meets statistics—A synergy for modern drug development

Yevgen Ryeznik, Oleksandr Sverdlov, Elin M. Svensson, Grace Montepiedra, Andrew C. Hooker, Weng Kee Wong

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

Modern drug development problems are very complex and require integration of various scientific fields. Traditionally, statistical methods have been the primary tool for design and analysis of clinical trials. Increasingly, pharmacometric approaches using physiology-based drug and disease models are applied in this context. In this paper, we show that statistics and pharmacometrics have more in common than what keeps them apart, and collectively, the synergy from these two quantitative disciplines can provide greater advances in clinical research and development, resulting in novel and more effective medicines to patients with medical need.

原文English
頁(從 - 到)1134-1149
頁數16
期刊CPT: Pharmacometrics and Systems Pharmacology
10
發行號10
DOIs
出版狀態Published - 2021 10月

All Science Journal Classification (ASJC) codes

  • 建模與模擬
  • 藥學(醫學)

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