Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns

Yung Ning Yang, Yu Chen S.H. Yang, I. Hsuan Lin, Ying Yu Chen, Hung Yun Lin, Chien Yi Wu, Yu Tsun Su, Yao-jong Yang, San Nan Yang, Jau Ling Suen

研究成果: Article

摘要

Postnatal exposure to di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, is associated with allergy development in childhood, suggesting that DEHP exposure may dysregulate immune response in infants. We investigated whether DEHP exposure in newborns through medical treatment affected the gut microbiota pattern and vaccine response, which are both related to immune development. In this prospective cohort study from May 1, 2016 through July 31, 2017, newborns with respiratory distress who were given intravenous infusions (IVs) were enrolled as the DEHP group, and newborns who did not receive IVs were enrolled as the control group. We excluded patients with perinatal maternal probiotics, vaginal delivery, antibiotic treatment, and exclusive human milk or formula feeding. Of 118 infants, urinary phthalate metabolite analysis revealed that the calculated DEHP concentrations of the newborns treated with IVs (n = 15) were higher than those in the control group (n = 10) (p = 0.0001). DEHP exposure altered bacterial communities both in composition and diversity, particularly decreases in Rothia sp. and Bifidobacterium longum in the DEHP group. Furthermore, DEHP exposure significantly enhanced anti-HBsAg-IgM responses in the DEHP group (p = 0.013). Early-life DEHP exposure alter gut microbiota of newborns and may change their immune responses in later life.

原文English
文章編號110700
期刊Food and Chemical Toxicology
132
DOIs
出版狀態Published - 2019 十月 1

指紋

phthalates
intestinal microorganisms
Immunoglobulin M
neonates
Vaccines
Newborn Infant
vaccines
Chemical analysis
Gastrointestinal Microbiome
phthalic acid
immune response
Allergies
bottle feeding
Bifidobacterium longum
Plasticizers
Control Groups
plasticizers
medical treatment
Probiotics
Human Milk

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

引用此文

Yang, Y. N., Yang, Y. C. S. H., Lin, I. H., Chen, Y. Y., Lin, H. Y., Wu, C. Y., ... Suen, J. L. (2019). Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns. Food and Chemical Toxicology, 132, [110700]. https://doi.org/10.1016/j.fct.2019.110700
Yang, Yung Ning ; Yang, Yu Chen S.H. ; Lin, I. Hsuan ; Chen, Ying Yu ; Lin, Hung Yun ; Wu, Chien Yi ; Su, Yu Tsun ; Yang, Yao-jong ; Yang, San Nan ; Suen, Jau Ling. / Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns. 於: Food and Chemical Toxicology. 2019 ; 卷 132.
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Phthalate exposure alters gut microbiota composition and IgM vaccine response in human newborns. / Yang, Yung Ning; Yang, Yu Chen S.H.; Lin, I. Hsuan; Chen, Ying Yu; Lin, Hung Yun; Wu, Chien Yi; Su, Yu Tsun; Yang, Yao-jong; Yang, San Nan; Suen, Jau Ling.

於: Food and Chemical Toxicology, 卷 132, 110700, 01.10.2019.

研究成果: Article

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AU - Wu, Chien Yi

AU - Su, Yu Tsun

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AU - Yang, San Nan

AU - Suen, Jau Ling

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