Phthalates metabolite levels as effective predictors for childhood allergic responses and reporting respiratory symptoms

Nai Yun Hsu, Ching Chang Lee, Yi Cheng Li, Hsin Wen Chang, Jiu Yao Wang, Chung Yu Chen, Carl Gustaf Bornehag, Pei Chih Wu, Jan Sundell, Huey Jen Su

研究成果: Conference contribution

摘要

The aim of this study was to characterize the association between phthalates exposure, through the representative biomarker, and childhood allergic and respiratory morbidity after adjusting for exposure to common indoor pollutants, especially bioaerosols. A total of 101 children were examined for their urinary metabolites of phthalates and indoor chemical or biological exposure. Children with higher urinary levels of phthalates are more likely to be categorized as "case" (aOR of MBzP=1.81, 95%CI=0.97-3.37), reporting higher frequency of parental reporting symptoms (aOR of MBzP=2.12, 95%CI=1.15-3.91), being found sensitized to inhalant (aOR of MBP=3.60, 95%CI=1.14-11.40) or mite allergens (aOR of MBP=2.48, 95%CI=1.34-4.62), and to present higher severity of physician-diagnosed diseases during clinic visits (β of MEHP=0.20, p=0.07). Moreover, I/O ratios of culturable fungi and endotoxin were also suggested as significant risks. The relative contribution from phthalates and indoor-originated bio-contaminants exposure on childhood allergic and respiratory morbidities is for the first time quantitatively characterized.

原文English
主出版物標題12th International Conference on Indoor Air Quality and Climate 2011
頁面157-162
頁數6
出版狀態Published - 2011 十二月 1
事件12th International Conference on Indoor Air Quality and Climate 2011 - Austin, TX, United States
持續時間: 2011 六月 52011 六月 10

出版系列

名字12th International Conference on Indoor Air Quality and Climate 2011
1

Other

Other12th International Conference on Indoor Air Quality and Climate 2011
國家United States
城市Austin, TX
期間11-06-0511-06-10

All Science Journal Classification (ASJC) codes

  • Pollution

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