Physanolide A, a novel skeleton steroid, and other cytotoxic principles from Physalis angulata

Ping-Chung Kuo, Tsung Hsiao Kuo, Amooru G. Damu, Chung Ren Su, E-Jian Lee, Tian-Shung Wu, Rexen Shu, Chou Ming Chen, Kenneth F. Bastow, Tzu Hsuan Chen, Kuo Hsiung Lee

研究成果: Article同行評審

56 引文 斯高帕斯(Scopus)

摘要

A novel withasteroid, physanolide A (1), with an unprecedented skeleton containing a seven-membered ring, and two new physalins, physalins U (2) and V (3), were isolated from Physalis angulata. The structures were elucidated from spectroscopic analysis, and plausible biosynthetic pathways were postulated. Physalins B (4), D (5), and F (6) showed strong cytotoxicity against multiple tumor cell lines, including KB, A431, HCT-8, PC-3, and ZR751, with EC 50 values less than 4 μg/mL

原文English
頁(從 - 到)2953-2956
頁數4
期刊Organic Letters
8
發行號14
DOIs
出版狀態Published - 2006 七月 6

All Science Journal Classification (ASJC) codes

  • 分子醫學

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