TY - JOUR
T1 - Physical processing for decellularized nerve xenograft in peripheral nerve regeneration
AU - Hsu, Ming Wei
AU - Chen, Szu Han
AU - Tseng, Wan Ling
AU - Hung, Kuo Shu
AU - Chung, Tzu Chun
AU - Lin, Sheng Che
AU - Koo, Jahyun
AU - Hsueh, Yuan Yu
N1 - Publisher Copyright:
Copyright © 2023 Hsu, Chen, Tseng, Hung, Chung, Lin, Koo and Hsueh.
PY - 2023
Y1 - 2023
N2 - In severe or complex cases of peripheral nerve injuries, autologous nerve grafts are the gold standard yielding promising results, but limited availability and donor site morbidity are some of its disadvantages. Although biological or synthetic substitutes are commonly used, clinical outcomes are inconsistent. Biomimetic alternatives derived from allogenic or xenogenic sources offer an attractive off-the-shelf supply, and the key to successful peripheral nerve regeneration focuses on an effective decellularization process. In addition to chemical and enzymatic decellularization protocols, physical processes might offer identical efficiency. In this comprehensive minireview, we summarize recent advances in the physical methods for decellularized nerve xenograft, focusing on the effects of cellular debris clearance and stability of the native architecture of a xenograft. Furthermore, we compare and summarize the advantages and disadvantages, indicating the future challenges and opportunities in developing multidisciplinary processes for decellularized nerve xenograft.
AB - In severe or complex cases of peripheral nerve injuries, autologous nerve grafts are the gold standard yielding promising results, but limited availability and donor site morbidity are some of its disadvantages. Although biological or synthetic substitutes are commonly used, clinical outcomes are inconsistent. Biomimetic alternatives derived from allogenic or xenogenic sources offer an attractive off-the-shelf supply, and the key to successful peripheral nerve regeneration focuses on an effective decellularization process. In addition to chemical and enzymatic decellularization protocols, physical processes might offer identical efficiency. In this comprehensive minireview, we summarize recent advances in the physical methods for decellularized nerve xenograft, focusing on the effects of cellular debris clearance and stability of the native architecture of a xenograft. Furthermore, we compare and summarize the advantages and disadvantages, indicating the future challenges and opportunities in developing multidisciplinary processes for decellularized nerve xenograft.
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U2 - 10.3389/fbioe.2023.1217067
DO - 10.3389/fbioe.2023.1217067
M3 - Short survey
AN - SCOPUS:85162010071
SN - 2296-4185
VL - 11
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
M1 - 1217067
ER -