TY - JOUR
T1 - Plasmon resonant two-photon luminescence inducing photosensitization and nonlinear optical microscopy in vivo by near-infrared excitation of au nanopeanuts
AU - Guo, Lun Zhang
AU - Wu, Cheng Ham
AU - Tsai, Ming Fong
AU - Cheng, Fong Yu
AU - Shanmugam, Vijayakumar
AU - Tsai, Zen Uong
AU - Zhang, Zhiming
AU - Liu, Tzu Ming
AU - Yeh, Chen Sheng
N1 - Funding Information:
Funding: This work was funded by the National Science Council, grant numbers NSC 100-2628-E-002-006, NSC 100-2627-M-006-007, and NSC 100-2119-M-006-021, the National Health Research Institute of Taiwan, grant number NHRI-EX101-9936EI, and The Science and Technology Development Fund, Macau SAR, File no. 122/2016/A3, 018/2017/A1, 0011/2019/AKP, 0120/2020/A3, and 0026/2021/A.
Funding Information:
Acknowledgments: This work was supported by the National Science Council (NSC 100-2628-E-002-006, NSC 100-2627-M-006-007 and NSC 100-2119-M-006-021), the National Health Research Institute (NHRI-EX101-9936EI) of Taiwan, and The Science and Technology Development Fund, Macau SAR (File no. 122/2016/A3, 018/2017/A1, FDCT/0011/2019/AKP, 0120/2020/A3, and 0026/2021/A).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/11
Y1 - 2021/11
N2 - Photodynamic therapy (PDT) provides a potential therapeutic approach for killing ma-lignant cell/solid tumors, but currently approved photosensitizers (PSs) are generally excited by visible light, limiting the penetration depth in tissues. It is necessary to develop a near-infrared (NIR) responsive photodynamic platform, providing maximum tissue penetration. Here, we present a gold nanopeanut platform exhibiting dual functions of NIR PDT and two-photon luminescence imaging. The nanopeanut with a size less than 100 nm exhibits two distinct NIR surface plasmon absorption bands at approximately 1110 and 1300 nm. To perform PDT, we conjugated commercial toluidine blue O (TBO) PS on the surface of the nanopeanuts. With spectral overlap, the 1230-nm femtosec-ond Cr: forsterite laser can excite the surface plasmons of nanopeanuts, transfer energy to TBO, and generate singlet oxygen to kill cells. Moreover, the plasmon resonance-enhanced two-photon luminescence of nanopeanuts can be used to map their delivery in vivo. These results demonstrate that the PS-conjugated gold nanopeanut is an effective theranostic system for NIR PDT.
AB - Photodynamic therapy (PDT) provides a potential therapeutic approach for killing ma-lignant cell/solid tumors, but currently approved photosensitizers (PSs) are generally excited by visible light, limiting the penetration depth in tissues. It is necessary to develop a near-infrared (NIR) responsive photodynamic platform, providing maximum tissue penetration. Here, we present a gold nanopeanut platform exhibiting dual functions of NIR PDT and two-photon luminescence imaging. The nanopeanut with a size less than 100 nm exhibits two distinct NIR surface plasmon absorption bands at approximately 1110 and 1300 nm. To perform PDT, we conjugated commercial toluidine blue O (TBO) PS on the surface of the nanopeanuts. With spectral overlap, the 1230-nm femtosec-ond Cr: forsterite laser can excite the surface plasmons of nanopeanuts, transfer energy to TBO, and generate singlet oxygen to kill cells. Moreover, the plasmon resonance-enhanced two-photon luminescence of nanopeanuts can be used to map their delivery in vivo. These results demonstrate that the PS-conjugated gold nanopeanut is an effective theranostic system for NIR PDT.
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U2 - 10.3390/app112210875
DO - 10.3390/app112210875
M3 - Article
AN - SCOPUS:85119841578
SN - 2076-3417
VL - 11
JO - Applied Sciences (Switzerland)
JF - Applied Sciences (Switzerland)
IS - 22
M1 - 10875
ER -