Platelet compatibility improvement by proper choice of acidic terminal functionality for mixed-charge self-assembled monolayers

Ching Hsiung Shen, Jui-Che Lin

研究成果: Article同行評審

10 引文 斯高帕斯(Scopus)

摘要

In this study two different series of mixed-charge self-assembled monolayers (SAMs) prepared with -N +(CH 3) 3-terminated alkanethiol and strong dissociated monovalent -SO 3H acid-terminated or weaker dissociated divalent -PO 3H 2 acid-terminated alkanethiol in pure ethanol were characterized. The influence of the acidity of the anionic functionality in the mixed-charge SAMs on the surface characteristics and platelet compatibility was investigated. X-ray photoelectron spectroscopy indicated that a nearly equivalent amount of countercharged terminal groups was noted on the surface of -SO 3H/-N +(CH 3) 3 mixed SAMs, while "-N +(CH 3) 3 thiol poor" phenomena were found on -PO 3H 2/-N +(CH 3) 3 mixed SAMs instead. This was caused by the distinct differences in solvation capability between the acidic anionic functional groups and solvent molecules and/or the interactions among the terminal ends of the thiols. This acidity difference also affected other interfacial properties and the platelet compatibility. The mixed SAMs formed from the mixture of -SO 3H- and -N +(CH 3) 3-terminated thiols showed higher surface hydrophilicity and exhibited the least amount of platelets adhered, but these two mixed SAMs were all fairly negatively surface charged. The structure of the hydration layer near the surfaces was likely affected by the acidity of the anionic functionality, and this would cause such a distinct behavior in platelet compatibility. It was concluded that the hydrophilic surfaces with nearly equal amounts of surface positively and negatively charged components could exhibit better platelet compatibility. This work demonstrated that the nature of the acidic terminal ends of alkanethiol is also a key factor for preparing mixed-charge SAMs with good platelet compatibility.

原文English
頁(從 - 到)640-647
頁數8
期刊Langmuir
28
發行號1
DOIs
出版狀態Published - 2012 1月 10

All Science Journal Classification (ASJC) codes

  • 電化學
  • 凝聚態物理學
  • 表面和介面
  • 一般材料科學
  • 光譜

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