Polymeric nanotherapeutics: Clinical development and advances in stealth functionalization strategies

Che-Ming Hu, Ronnie H. Fang, Brian T. Luk, Liangfang Zhang

研究成果: Article

113 引文 斯高帕斯(Scopus)

摘要

Long-circulating polymeric nanotherapeutics have garnered increasing interest in research and in the clinic owing to their ability to improve the solubility and pharmacokinetics of therapeutic cargoes. Modulation of carrier properties promises more effective drug localization at the disease sites and can lead to enhanced drug safety and efficacy. In the present review, we highlight the current development of polymeric nanotherapeutics in the clinic. In light of the importance of stealth properties in therapeutic nanoparticles, we also review the advances in stealth functionalization strategies and examine the performance of different stealth polymers in the literature. In addition, we discuss the recent development of biologically inspired "self" nanoparticles, which present a differing stealth concept from conventional approaches.

原文English
頁(從 - 到)65-75
頁數11
期刊Nanoscale
6
發行號1
DOIs
出版狀態Published - 2014 一月 7

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

指紋 深入研究「Polymeric nanotherapeutics: Clinical development and advances in stealth functionalization strategies」主題。共同形成了獨特的指紋。

  • 引用此